Table 2 Genotype and allele frequencies of TaqI, BmsI, ApaI and FokI polymorphisms of the VDR gene in intervertebral disc degeneration and control group
VDR SNPs | Population | N | Genotypes | HWE | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | p* | OR (95% CI) | n (%) | p* | OR (95% CI) | ||||
TaqI T>C | TT | TC | CC | |||||||
DD | 119 | 50 (42%) | 42 (35%) | Ref. | 27 (23%) | Ref. | Ref. | 0.015 | ||
Controls | 112 | 52 (46%) | 46 (41%) | 0.858 | 0.95 (0.54–1.68) | 14 (13%) | 0.067 | 2.01 (0.94–4.26) | 0.750 | |
BsmI G>A | GG | GA | AA | |||||||
DD | 119 | 52 (44%) | 67 (56%) | Ref. | 0 (0%) | – | – | < 0.001 | ||
Controls | 112 | 51 (46%) | 61 (54%) | 0.778 | 1.08 (0.64–1.81) | 0 (0%) | < 0.001 | |||
ApaI G>T | GG | GT | TT | |||||||
DD | 119 | 37 (31%) | 64 (54%) | Ref. | 18 (15%) | Ref. | Ref. | 0.527 | ||
Controls | 112 | 39 (35%) | 59 (53%) | 0.645 | 1.14 (0.65–2.03) | 14 (12%) | 0.472 | 1.36 (0.59–3.11) | 0.515 | |
FokI T>C | TT | TC | CC | |||||||
DD | 119 | 53 (44.5%) | 49 (41.2%) | Ref. | 17 (14.3%) | Ref. | Ref. | 0.595 | ||
Controls | 112 | 61 (54.5%) | 41 (36.6%) | 0.259 | 1.38 (0.79–2.040) | 10 (8.9%) | 0.123 | 1.96 (0.83–4.64) | 0.722 | |
VDR SNPs | Population | N | Alleles | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | p* | OR (95% CI) | |||||||
TaqI T>C | T | C | ||||||||
DD | 142 (59.7) | 96 (40.3) | Ref. | |||||||
Controls | 150 (67.0) | 74 (33.0) | 0.103 | 1.37 (0.94–2.00) | ||||||
BsmI G>A | G | A | ||||||||
DD | 171 (71.8) | 67 (28.2) | Ref. | |||||||
Controls | 163 (72.8) | 61 (27.2) | 0.824 | 1.05 (0.70–1.57) | ||||||
ApaI G>T | G | T | ||||||||
DD | 138 (58.0) | 100 (42.0) | Ref. | |||||||
Controls | 137 (61.2) | 87 (38.8) | 0.486 | 1.14 (0.79–1.66) | ||||||
FokI T>C | T | C | ||||||||
DD | 155 (65.1) | 83 (34.9) | Ref. | |||||||
Controls | 163 (72.8) | 61 (27.2) | 0.076 | 1.43 (0.96–2.13) | ||||||