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Table 2 Genotype and allele frequencies of TaqI, BmsI, ApaI and FokI polymorphisms of the VDR gene in intervertebral disc degeneration and control group

From: Influence of lifestyle characteristics and VDR polymorphisms as risk factors for intervertebral disc degeneration: a case–control study

VDR SNPs Population N Genotypes HWE
n (%) n (%) p* OR (95% CI) n (%) p* OR (95% CI)
TaqI
T>C
   TT TC    CC    
DD 119 50 (42%) 42 (35%)   Ref. 27 (23%) Ref. Ref. 0.015
Controls 112 52 (46%) 46 (41%) 0.858 0.95 (0.54–1.68) 14 (13%) 0.067 2.01 (0.94–4.26) 0.750
BsmI
G>A
   GG GA    AA    
DD 119 52 (44%) 67 (56%)   Ref. 0 (0%) < 0.001
Controls 112 51 (46%) 61 (54%) 0.778 1.08 (0.64–1.81) 0 (0%)    < 0.001
ApaI
G>T
   GG GT    TT    
DD 119 37 (31%) 64 (54%)   Ref. 18 (15%) Ref. Ref. 0.527
Controls 112 39 (35%) 59 (53%) 0.645 1.14 (0.65–2.03) 14 (12%) 0.472 1.36 (0.59–3.11) 0.515
FokI
T>C
   TT TC    CC    
DD 119 53 (44.5%) 49 (41.2%)   Ref. 17 (14.3%) Ref. Ref. 0.595
Controls 112 61 (54.5%) 41 (36.6%) 0.259 1.38 (0.79–2.040) 10 (8.9%) 0.123 1.96 (0.83–4.64) 0.722
VDR SNPs Population N Alleles     
n (%) n (%) p* OR (95% CI)     
TaqI
T>C
   T C       
DD   142 (59.7) 96 (40.3)   Ref.     
Controls   150 (67.0) 74 (33.0) 0.103 1.37 (0.94–2.00)     
BsmI
G>A
   G A       
DD   171 (71.8) 67 (28.2)   Ref.     
Controls   163 (72.8) 61 (27.2) 0.824 1.05 (0.70–1.57)     
ApaI
G>T
   G T       
DD   138 (58.0) 100 (42.0)   Ref.     
Controls   137 (61.2) 87 (38.8) 0.486 1.14 (0.79–1.66)     
FokI
T>C
   T C       
DD   155 (65.1) 83 (34.9)   Ref.     
Controls   163 (72.8) 61 (27.2) 0.076 1.43 (0.96–2.13)     
  1. DD intervertebral disc degeneration, SNPs single nucleotide polymorphism, OR odds ratio, CI confidence interval, HWE Hardy–Weinberg equilibrium
  2. Ref. Reference category
  3. * Chi square test