Clinical evaluation of haploidentical hematopoietic combined with human umbilical cord-derived mesenchymal stem cells in severe aplastic anemia

Table 1 Clinical features of patients and their donors as well as the outcomes of 24 cases

Case	Sex/age	Donor/age	HLA -matched	ABO pairs D/R	MNC 108/kg	CD34⁺ 106/kg	ANC > 2 × 109/L (D)	PLT > 20 × 109/L (D)	aGVHD grade/cGVHD grade	Outcome (M)
1	F/25	Mother/47	3/6	B/AB	9.43	1.9	12	15	–/–	Dead 3
2	M/14	Mother/39	3/6	O/B	10.96	12.83	12	13	–/–	Dead 3
3	M/5	Mother/30	4/6	AB/B	10.2	2.79	12	13	III/Ext	Dead 12
4	M/9	Sister/22	5/6	O/O	10.37	3.24	10	12	IV/Ext	Alive 12
5	M/23	Mother/51	4/6	B/B	8.1	2.97	10	14	–/Ext	Alive 10
6	F/18	Brother/22	3/6	O/O	10.56	4.546	10	14	II/Lim	Alive 13
7	M/16	Father/43	3/6	B/B	8.82	3.25	10	14	III/–	Alive 13
8	M/13	Mother/33	3/6	0/A	10.97	3.47	9	10	III/–	Alive 11
9	M/22	Father/41	4/6	O/A	10.06	3.79	8	14	IV/–	Dead 4
10	F/9	Mother/31	3/6	A/A	9.62	4.71	10	12	–/–	Alive 10
11	M/21	Father/45	3/6	A/A	10.83	4.02	11	13	–/–	Alive 11
12	M/25	Mother/48	3/6	A/AB	8.05	3.45	13	13	II/–	Alive 19
13	F/25	Mother/47	3/6	A/A	12.47	18.65	11	15	III/–	Alive 17
14	F/8	Mother/32	3/6	A/A	10.03	5.33	12	15	I/–	Alive 16
15	M/16	Father/43	3/6	B/B	13.18	7.96	13	15	–/–	Alive 15
16	F/17	Sister/27	3/6	B/B	6.3	3.75	21	25	–/–	Alive 20
17	F/13	Mother/46	4/6	O/AB	9.96	10.2	12	12	I/–	Alive 27
18	M/17	Father/37	3/6	O/O	9.36	7.52	11	13	I/Lim	Alive 41
19	F/24	Sister/21	4/6	A/A	9.66	6.94	11	13	–/–	Alive 41
20	M/20	Sister/23	3/6	B/AB	9.28	5.08	16	18	I/Lim	Alive 44
21	M/15	Mother/37	4/6	O/O	7.93	3.76	8	10	–/–	Dead 3
22	F/13	Sister/18	5/6	B/B	11.2	12.56	10	10	–/–	Alive 4
23	M/8	Mother/32	3/6	A/A	8.1	3.94	10	12	–/–	Alive 5
24	F/55	Brother/49	3/6	O/B	9.24	4.72	10	11	–/–	Alive 12

F female, M male, HLA human leukocyte antigen, D donor, R recipient, MNC mononuclear cells, ANC absolute neutrophil count, PLT platelets, aGVHD acute graft-versus-host disease, cGVHD chronic graft-versus-host disease, Ext extensive, Lim limited, D day, M months

ISSN: 2047-783X