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Table 1 Comparison on demographic and clinical data for NPE and CNSD children patients

From: Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand–foot–mouth disease

  NPE group CNSD group P value
N 42 47 0.015
Age (months, \( \bar{x} \pm s \)) 17.55 ± 5.12 22.94 ± 10.37 0.552
Boy (cases, (%)) 23 (54.76) 30 (63.83) 0.257
Body mass (kg, \( \bar{x} \pm s \)) 11.86 ± 2.02 12.72 ± 2.71  
Residence    0.267
 City 10 (23.81) 13 (27.66)  
 Rural area 22 (52.38) 22 (46.81)  
 Rural–urban fringe zone 10 (23.81) 12 (25.53)  
Length of stay (days) median (P25 and P75) 8 (6,9) 6 (5,7) 0.000
Maximum body temperature (°C, \( \bar{x} \pm s \)) 38.89 ± 0.60 38.73 ± 0.80 0.480
Duration of fever (days) median (P25 and P75) 4 (4,5) 3 (2,4) 0.000
Cardiac rhythm (times/min, \( \bar{x} \pm s \)) 227.21 ± 28.23 161.09 ± 23.31 0.000
EV71-positive cases (%) 37 (88.10) 29 (61.70) 0.024
White blood cell count (×109/L, \( \bar{x} \pm s \)) 13.75 ± 3.68 12.84 ± 2.78 0.033
CRP (mg/L, \( \bar{x} \pm s \)) 15.43 ± 10.31 9.83 ± 6.28 0.898
Blood sugar (mmol/L, \( \bar{x} \pm s \)) 7.58 ± 1.83 6.16 ± 1.14 0.003
IVI therapy cases (%) 37 (88.10) 38 (80.85) 0.786
Hormonal therapy cases (%) 40 (95.24) 43 (91.49) 0.901
  1. CNSD, central nervous system disease; NEP, neurogenic pulmonary edema; CPR, C-reactive protein; EV71, human enterovirus 71; IVIG, intravenous immune globulin
  2. at test; b χ2 test; c Mann–Whitney U test