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Table 5 Clinical data of fourteen patients with special site HP treated with surgery

From: Clinical analysis of 50 patients with heterotopic pregnancy after ovulation induction or embryo transfer

Case

Fertilization way (embryo type and number if ET)

Gestational age (days after ET or intercourse)

Clinical symptoms

Presentation and outcome of IUP

Extrauterine pregnancy presentation

Bilateral fallopian tubes

EP site + treatment

37

IVF-ET (fresh 2)

28

Vaginal bleeding 24 days

CRL 0.3 cm, heart beaten

Right adnexal mass 2 cm CRL 0.2 cm without heart beaten

Right salpingectomy and left ligament for EP

Tubal stumps + laparotomy tubal stumps resection

38

IVF-ET (frozen 2)

18

Vaginal bleeding 12 days

Yolk sac without embryonic pole → live birth

Left adnexal mass 7 cm, yolk sac without embryonic pole

Left isthmus ligament

Tubal stumps + laparotomy tubal stumps and part cornual resection

39

IVF-ET (fresh 2)

57

Vaginal bleeding 3 days

CRL 3.7 cm, heart beaten

Left cornual CRL 3.2 cm with heart beaten (3 weeks later)

Bilateral tubal unobstructed by HSG, history of pelvic surgery

Interstitial + laparotomy salpingectomy and part cornual resection

40

IVF-ET (frozen 3)

26

Abdominal pain 3 day

CRL 0.2 cm, heart beaten

Left adnexal mass 4 cm

Bilateral salpingectomy for EP

posterior uterine + laparotomy mass removal, abdominal haematocele 1400 ml

41

IVF-ET (unknown)

> 70

Abdominal pain and vaginal bleeding 12 + days

CRL 4.7 cm, heart beaten

Left fundus mass 5 cm

Left tubal hydrosalpinx

Interstitial + laparotomy salpingectomy and cornual resection

42

IVF-ET (fresh 2)

46

Vaginal bleeding and abdominal distension 6 days

CRL 0.3 cm, live birth→missed abortion

Right adnexal mass 4 cm, CRL1.8 cm without heart beaten

Bilateral salpingectomy

Cornual EP ruption + laparotomy cornual removal,abdominal haematocele 2000 ml

43

IVF-ET (unknown)

22

Vaginal bleeding 11 days and abdominal pain 3 days

Abortion

Mass behind uterus 9 cm

Bilateral unobstructed by laparoscope

Abdominal gestation + laparotomy mass removal

44

IVF-ET (frozen 3)

39

Asymptomatic, routine ultrasound test found

CRL 0.4 cm without heart beaten → missed abortion

Right cornual mass 2.5 cm

Right salpingectomy for EP and left salpingostomy for hydrosalpinx

Interstitial + laparoscopy part cornual resection and local MTX 20 mg

45

Ovulation induction + spontaneous

> 63

Asymptomatic, routine ultrasound test found

CRL 2.6 cm, heart beaten

Right interstitial portion mass 5 cm CRL 2.4 cm, with heart beaten

Left tubal obstructed and right tubal unobstructed by HSG

Interstitial + laparotomy salpingectomy and part cornual resection

46

IVF-ET (frozen 2)

32

Asymptomatic, routine ultrasound test found

CRL 0.6 cm, heart beaten

Left cornual CRL 0.7 cm with heart beaten

Left salpingectomy and right tubal repair surgery

Interstitial + laparotomy part cornual resection

47

IVF-ET (frozen 2)

35

Asymptomatic, routine ultrasound test found

CRL 1.2 cm, heart beaten

Right cornual CRL 0.7 cm with heart beaten

Right salpingectomy and cornual resection both for EP

Cornual–interstitial EP + laparotomy salpingostomy

48

IVF-ET (fresh 2)

36

Asymptomatic, routine ultrasound test found

CRL 1.1 cm, heart beaten

Right cornual CRL 1.1 cm with heart beaten

Bilateral salpingectomy

Cornual ruption + laparotomy cornual resection

49

IVF-ET (frozen 3)

38

Asymptomatic, routine ultrasound test found

CRL 1.2 cm, heart beaten

Right adnexal mass 3 cm

Bilateral tubal obstructed by HSG

Interstitial + laparotomy salpingectomy and cornual resection

50

Ovulation induction + spontaneous

30

Nausea and vomiting

CRL 3.1, 3.2, 4.4 and 1.9 cm all with heart beaten

Right adnexal mass 3 cm

Ovulation induction for PCOS and bilateral tubal unobstructed by HSG

Isthmic EP ruption + laparotomy salpingectomy, abdominal haematocele 2000 ml