Table 2 Studies characteristics of each article included in the meta-analysis and distribution of genotype frequency of GSTM1 among controls and cirrhotic patients
First author | Year | Country | Cirrhosis type | Sample size (case/control) | Genotyping method | Control source | Matched factors | Score | Case group | Control group | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
GSTM1 active, N (%) | GSTM1 null, N (%) | GSTM1 active, N (%) | GSTM1 null, N (%) | |||||||||
Khan [18] | 2010 | India | Alcoholic HC | 140/175 | Multiple PCR | HB | Age, ethnicity, region | 8 | 98 (56.0%) | 77 (44.0%) | 96 (68.5%) | 44 (31.5%) |
Khan [19] | 2009 | India | Alcoholic HC | 160/100 | Multiple PCR | HB | Region | 8 | 92 (57.0%) | 68 (43.0%) | 70 (70.0%) | 30 (30.0%) |
Burim [21] | 2004 | Brazil | Alcoholic HC | 65/221 | Multiple PCR | HB | Age, gender, ethnicity, drink habits | 9 | 35 (53.8%) | 30 (46.2%) | 120 (54.3%) | 101 (45.8%) |
Frenzer [20] | 1999 | Australia | Alcoholic HC | 57/57 | Multiple PCR | HB | Age, ethnicity, drink habits | 8 | 3 (5.3%) | 54 (94.7%) | 10 (17.5%) | 47 (82.5%) |
Rodrigo [22] | 2005 | Spain | Alcoholic HC | 120/200 | PCR–RFLP | PB | Sex, region | 6 | 51 (42.5%) | 69 (57.5%) | 90 (45.0%) | 110 (55.0%) |
Davies [23] | 1993 | Birmingham | Primary biliary HC | 44/68 | Horizontal starch gel electrophoresis | HB | None | 5 | 27 (61.0%) | 17 (39.0%) | 37 (54.4%) | 31 (45.6%) |