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Table 2 Distribution of genotype and allele frequencies of TP53 codon 72 and 16-bp duplication polymorphisms in breast cancer cases and controls

From: No association of TP53 codon 72 and intron 3 16-bp duplication polymorphisms with breast cancer risk in Chinese Han women: new evidence from a population-based case–control investigation

Polymorphism Genotype BC cases Controls Padj valuea OR aadj (95% CI) Armitage’s trend test
Codon 72 Additive model
 Arg/Arg 66 (26.0%) 82 (32.5%)   Reference Ptrend = 0.58
OR trend = 1.05
 Arg/Pro 149 (58.7%) 123 (48.8%) 0.10 1.43 (0.93–2.18)
 Pro/Pro 39 (15.3%) 47 (18.7%) 0.72 1.11 (0.63–1.95)
Dominant model
 Arg/Arg 66 (26.0%) 82 (32.5%)   Reference
 Arg/Pro + Pro/Pro 188 (74.0%) 170 (67.5%) 0.16 1.34 (0.89–2.02)
Recessive model
 Arg/Arg + Arg/Pro 215 (84.7%) 205 (81.3%)   Reference
 Pro/Pro 39 (15.3%) 47 (18.7%) 0.62 0.88 (0.54–1.44)
Allele  Arg 281 (55.3%) 287 (56.9%)   Reference
 Pro 227 (44.7%) 217 (43.1%) 0.52 1.09 (0.84–1.42)
16-bp duplication Additive model Ptrend = 0.86
OR trend  = 0.95
 Del/Del 230 (90.6%) 227 (90.1%)   Reference
 Del/Ins 24 (9.4%) 25 (9.9%) 0.58 0.84 (0.44–1.58)
 Ins/Ins 0 (–) 0 (–)
Dominant model
 Del/Del 230 (90.6%) 227 (90.1%)   Reference
 Del/Ins + Ins/Ins 24 (9.4%) 25 (9.9%) 0.58 0.84 (0.44–1.58)
Recessive model
 Del/Del + Del/Ins 254 (100%) 252 (100%)   Reference
 Ins/Ins 0 (–) 0 (–)
Allele  Del 484 (95.3%) 479 (95.0%)   Reference
 Ins 24 (4.7%) 25 (5.0%) 0.59 0.84 (0.45–1.57)
  1. BC cases breast cancer cases, OR odds ratio, CI confidence interval
  2. aAdjusted by age