Fig. 3

Three-dimensional reconstruction of the knee joint before and after 12 months of treatment with BIOF2. It shows the bone region (yellow) and cartilaginous region (white) of the joint in an anterolateral view (a, b) and a posterior view (c, d). The image corresponds to the patient that had the greatest increase in cartilage (43%). Femur and tibia cartilage fusion observed in some regions of the a or b images, corresponds to a defect in the three-dimensional reconstruction, in which the virtual space between the two structures, at that point in particular, was not able to be distinguished