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Table 3 Pathological features of eight neuroendocrine carcinoma cases

From: Neuroendocrine carcinoma of gallbladder: a case series and literature review

No.

Location

Size (cm)

Type

TNM grade

Ki-67 (%)

Immunohistochemistry

With adenoma

With gallstone

1

Body

3.4 × 1.7

NA

T4N0M0

40

CEA (+), CDX2 (+), CGA (+), syn (+), CAM5.2 (+), CK19 (partly +), p53 (+)

Yes

No

2

Body

3.1 × 1.6

NA

T4N0M0

12–60

CK7 (−), CD56 (−), CGA (+), syn (+), EMA (+)

Yes

No

3

Body

2.1 × 1.0

NA

T3N1M0

70

CD3 (−), CK20 (−), CD56 (+), CGA (+), syn (+), alk-sp8 (−), BCL (−), CD10 (−), CD30 (−), MUM-1 (−)

No

No

4

Body

2.4 × 1.8

Large cell

T3N0M0

85

CDX2 (−), CK7 (+), CK20 (−), CGA (+), syn (+)

Yes

No

5

Body

2.7 × 2.2

Small cell

T3N2M0

80

CD3 (−), CK20 (−), CD56 (−), CGA (+), syn (+), s100 (−), vimentin (−)

No

No

6

Fundus

1.9 × 0.9

Small cell

T1N0M0

80

CD3 (−), CK20 (−), CGA (+), syn (+), MUC (−), P53 (−), SMA (−)

Yes

Yes

7

Body

1.7 × 1.4

Large cell

T1N0M0

40

CK19 (+), CGA (+), syn (+), CAM5.2 (+), CK20 (−), p53 (+)

Yes

No

8

Body

1.5 × 1.2

NA

T1N0M0

80

CK20 (−), CGA (+), syn (+), s100 (−), vimentin (−), CD3 (−)

No

No

  1. CD cluster of differentiation antigen, CDX2 caudal type homeobox transcription factor 2, CEA carcino embryonie antigen, CGA chromogranin A, CK cytokeratin, EMA epithelial membrane antigen, syn synaptophysin, NA not available