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Table 3 Pathological features of eight neuroendocrine carcinoma cases

From: Neuroendocrine carcinoma of gallbladder: a case series and literature review

No. Location Size (cm) Type TNM grade Ki-67 (%) Immunohistochemistry With adenoma With gallstone
1 Body 3.4 × 1.7 NA T4N0M0 40 CEA (+), CDX2 (+), CGA (+), syn (+), CAM5.2 (+), CK19 (partly +), p53 (+) Yes No
2 Body 3.1 × 1.6 NA T4N0M0 12–60 CK7 (−), CD56 (−), CGA (+), syn (+), EMA (+) Yes No
3 Body 2.1 × 1.0 NA T3N1M0 70 CD3 (−), CK20 (−), CD56 (+), CGA (+), syn (+), alk-sp8 (−), BCL (−), CD10 (−), CD30 (−), MUM-1 (−) No No
4 Body 2.4 × 1.8 Large cell T3N0M0 85 CDX2 (−), CK7 (+), CK20 (−), CGA (+), syn (+) Yes No
5 Body 2.7 × 2.2 Small cell T3N2M0 80 CD3 (−), CK20 (−), CD56 (−), CGA (+), syn (+), s100 (−), vimentin (−) No No
6 Fundus 1.9 × 0.9 Small cell T1N0M0 80 CD3 (−), CK20 (−), CGA (+), syn (+), MUC (−), P53 (−), SMA (−) Yes Yes
7 Body 1.7 × 1.4 Large cell T1N0M0 40 CK19 (+), CGA (+), syn (+), CAM5.2 (+), CK20 (−), p53 (+) Yes No
8 Body 1.5 × 1.2 NA T1N0M0 80 CK20 (−), CGA (+), syn (+), s100 (−), vimentin (−), CD3 (−) No No
  1. CD cluster of differentiation antigen, CDX2 caudal type homeobox transcription factor 2, CEA carcino embryonie antigen, CGA chromogranin A, CK cytokeratin, EMA epithelial membrane antigen, syn synaptophysin, NA not available