Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better

Table 2 Differences for psychosocial, neuropsychological, and clinical assessment pre (t0) and after 6 weeks (t1) post-MitraClip intervention

	MC group (N = 40) Mean (SD)		t	p
	t0	t1	t	p
Psychosocial functioning^a
Depression-score (PHQ-9; 0–27)	6.44 (4.45)	3.78 (3.15)	4.57	< .001
Psychological well-being (SF-36; 0–100)	68.75 (22.50)	77.88 (15.57)	− 2.83	0.008
Physical well-being (SF-36; 0–100)	43.66 (25.02)	59.84 (26.79)	− 3.81	0.001
Cognitive functioning
Figural memory learning sum (FGT; 0–45)	18.23 (8.98)	24.55 (8.34)	− 7.29	< .001
Planning ability (TOL; 0–24)	11.75 (4.14)	15.25 (3.36)	− 4.83	< .001
Cognitive flexibility (TMT: Part B) [s]	120.15 (63.54)	99.35 (47.83)	3.82	< .001
Clinical parameters
LVEF	34.60 (14.95)	34.57 (15.64)	0.03	n.s.
6-MWT [s]	365.69 (6.64)	414.52 (115.40)	− 3.57	0.001
FMR	2.83 (0.64)	1.35 (0.48)	12.43	< .001
NYHA	3.05 (0.54)	2.34 (.49)	8.14	< .001
NT-ProBNP	10,161.9 (20,141.1)	8159.5 (16,704.3)	2.28	0.029

PHQ-9 Patient Health Questionnaire, SF-36 Short-Form Health Survey, FGT figural memory test, TOL, Tower of London–Freiburg Version, TMT-L trail making test–Langensteinbach version, LVEF left ventricular ejection fraction, 6-MWT 6-minute walk test, FMR functional mitral valve regurgitation, NT-ProBNP N-terminal pro-brain natriuretic peptide; Values are presented means, standard deviations, t value and p value. ^aPsychosocial assessment for N = 32

ISSN: 2047-783X