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Table 2 Differences for psychosocial, neuropsychological, and clinical assessment pre (t0) and after 6 weeks (t1) post-MitraClip intervention

From: Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better

  MC group (N = 40) Mean (SD) t p
t0 t1
Psychosocial functioninga
 Depression-score (PHQ-9; 0–27) 6.44 (4.45) 3.78 (3.15) 4.57 < .001
 Psychological well-being (SF-36; 0–100) 68.75 (22.50) 77.88 (15.57) − 2.83 0.008
 Physical well-being (SF-36; 0–100) 43.66 (25.02) 59.84 (26.79) − 3.81 0.001
Cognitive functioning
 Figural memory learning sum (FGT; 0–45) 18.23 (8.98) 24.55 (8.34) − 7.29 < .001
 Planning ability (TOL; 0–24) 11.75 (4.14) 15.25 (3.36) − 4.83 < .001
 Cognitive flexibility (TMT: Part B) [s] 120.15 (63.54) 99.35 (47.83) 3.82 < .001
Clinical parameters
 LVEF 34.60 (14.95) 34.57 (15.64) 0.03 n.s.
 6-MWT [s] 365.69 (6.64) 414.52 (115.40) − 3.57 0.001
 FMR 2.83 (0.64) 1.35 (0.48) 12.43 < .001
 NYHA 3.05 (0.54) 2.34 (.49) 8.14 < .001
 NT-ProBNP 10,161.9 (20,141.1) 8159.5 (16,704.3) 2.28 0.029
  1. PHQ-9 Patient Health Questionnaire, SF-36 Short-Form Health Survey, FGT figural memory test, TOL, Tower of London–Freiburg Version, TMT-L trail making test–Langensteinbach version, LVEF left ventricular ejection fraction, 6-MWT 6-minute walk test, FMR functional mitral valve regurgitation, NT-ProBNP N-terminal pro-brain natriuretic peptide; Values are presented means, standard deviations, t value and p value. aPsychosocial assessment for N = 32