From: Clinical versus histological grading in the assessment of cutaneous graft versus host disease
Clinical grading acute GvHDa | Total clinical grade acute GvHDa | Clinical grading chronic GvHDc | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Grade per organ | Involvement skin: % body surface area | Involvement GI: volume diarrhea (ml/day) | Involvement liver: level bilirubin (μmol/l) | Total grade aGvHD | Skin grade | GI grade | Liver grade | Clinical performance | Grade | Criteria |
0 | No rash caused by GvHD | < 500 | < 20 | 0 | 0 | 0 | 0 | Normal | Limited | Only involvement of skin and liver |
1 | < 25% | 500–1000; or nausea and vomiting with positive biopsy | 20–40; with moderate increase in ASAT (150–170 IU) | 1 | 1–2 | 0 | 0 | Normal | Extensive | Involvement of skin, liver, and any other organ |
2 | 25–50% | 1000–1500; or more severe nausea and vomiting | 40–75 | 2b | 1–3 | 1 | 1 | Mildly decreased | ||
3 | > 50% | 1500–2000; or more severe nausea and vomiting | 75–200 | 3b | 2–3 | 2–3 | 2–4 | Markedly decreased | ||
4 | > 50% with bullous formation or desquamation | > 2000; or severe abdominal pain with or without ileus | > 200 | 4 | 2–4 | 2–4 | 2–4 | Extremely decreased |