Table 4 Patients’ statistics (with survival comparison), each biopsy being a single event
From: Clinical versus histological grading in the assessment of cutaneous graft versus host disease
Biopsy statistics (with survival comparison) | ||||
|---|---|---|---|---|
Feature | Grouping/specifics | Frequency | % | p value |
Number of biopsies | N | 120 | 100.0% | |
Clinical GvHD | ||||
Overall (not aGvHD or cGvHD specified) | Graded based on % skin involvement | 117 | 97.5% | 1.668 |
No GvHD (0%) | 1 | |||
Grade 1 (< 25%) | 24 | |||
Grade 2 (25–50%) | 57 | |||
Grade 3 (> 50%) | 35 | |||
Grade based on involved tracts | 118 | 0.4059 | ||
Limited (only skin and liver) | 67 | |||
Extensive (involvement of skin, liver, and any other organ) | 51 | |||
Clinical acute GvHD at date biopsy | Overall grade (all tracts included) | 66 | 55.0% | 0.6812 |
No aGvHD | 1 | |||
Grade 1 | 10 | |||
Grade 2 | 33 | |||
Grade 3 | 23 | |||
Grade 4 | 0 | |||
Grade skin | 66 | 55.0% | 0.7702 | |
No aGvHD | 0 | |||
Grade 1 | 7 | |||
Grade 2 | 59 | |||
Grade 3 | 24 | |||
Grade 4 | 0 | |||
Clinical chronic GvHD at date biopsy | Overall grade (all tracts included) | 48 | 40.0% | 0.1062 |
Limited | 15 | |||
Extensive | 33 | |||
“Grade” skin (% skin involvement) | 48 | 40.0% | ||
No skin involvement | 0 | 0.5231 | ||
< 50% skin involved (limited) | 35 | |||
> 50% skin involved (extensive) | 13 | |||
Histological GvHD | ||||
Histological acute GvHD in biopsy | Histological acute grade (Horn) | 117 | 97.5% | 0.9509 |
No aGvHD | 8 | |||
Grade 1 | 47 | |||
Grade 2 | 54 | |||
Grade 3 | 8 | |||
Histological chronic GvHD in biopsy | Histological chronic/sclerosis grade | 115 | 95.8% | 0.829 |
No sclerosis | 10 | |||
Limited | 30 | |||
Extensive | 75 | |||
Biopsies of patients presenting with clinical aGvHD | Histological acute grade (Horn) | 66 | 55.0% | 0.8111 |
No aGvHD | 3 | |||
Grade 1 | 25 | |||
Grade 2 | 34 | |||
Grade 3 | 4 | |||
Histological chronic/sclerosis grade | 64 | 53.3% | 0.5068 | |
No sclerosis | 7 | |||
Limited | 16 | |||
Extensive | 41 | |||
Biopsies of patients presenting with clinical cGvHD | Histological acute grade (horn) | 46 | 38.3% | 0.8306 |
No aGvHD | 5 | |||
Grade 1 | 20 | |||
Grade 2 | 17 | |||
Grade 3 | 4 | |||
Histological chronic/sclerosis grade | 46 | 38.3% | 0.7996 | |
No sclerosis | 3 | |||
Limited | 14 | |||
Extensive | 29 | |||