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Table 4 Patients’ statistics (with survival comparison), each biopsy being a single event

From: Clinical versus histological grading in the assessment of cutaneous graft versus host disease

Biopsy statistics (with survival comparison)
Feature Grouping/specifics Frequency % p value
Number of biopsies N 120 100.0%  
Clinical GvHD
 Overall (not aGvHD or cGvHD specified) Graded based on % skin involvement 117 97.5% 1.668
  No GvHD (0%) 1   
  Grade 1 (< 25%) 24   
  Grade 2 (25–50%) 57   
  Grade 3 (> 50%) 35   
Grade based on involved tracts 118   0.4059
  Limited (only skin and liver) 67   
  Extensive (involvement of skin, liver, and any other organ) 51   
  Clinical acute GvHD at date biopsy Overall grade (all tracts included) 66 55.0% 0.6812
  No aGvHD 1   
  Grade 1 10   
  Grade 2 33   
  Grade 3 23   
  Grade 4 0   
Grade skin 66 55.0% 0.7702
  No aGvHD 0   
  Grade 1 7   
  Grade 2 59   
  Grade 3 24   
  Grade 4 0   
  Clinical chronic GvHD at date biopsy Overall grade (all tracts included) 48 40.0% 0.1062
  Limited 15   
  Extensive 33   
“Grade” skin (% skin involvement) 48 40.0%  
  No skin involvement 0   0.5231
  < 50% skin involved (limited) 35   
  > 50% skin involved (extensive) 13   
Histological GvHD
 Histological acute GvHD in biopsy Histological acute grade (Horn) 117 97.5% 0.9509
  No aGvHD 8   
  Grade 1 47   
  Grade 2 54   
  Grade 3 8   
 Histological chronic GvHD in biopsy Histological chronic/sclerosis grade 115 95.8% 0.829
  No sclerosis 10   
  Limited 30   
  Extensive 75   
 Biopsies of patients presenting with clinical aGvHD Histological acute grade (Horn) 66 55.0% 0.8111
  No aGvHD 3   
  Grade 1 25   
  Grade 2 34   
  Grade 3 4   
Histological chronic/sclerosis grade 64 53.3% 0.5068
  No sclerosis 7   
  Limited 16   
  Extensive 41   
 Biopsies of patients presenting with clinical cGvHD Histological acute grade (horn) 46 38.3% 0.8306
  No aGvHD 5   
  Grade 1 20   
  Grade 2 17   
  Grade 3 4   
Histological chronic/sclerosis grade 46 38.3% 0.7996
  No sclerosis 3   
  Limited 14   
  Extensive 29