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Table 5 General statistics with kappa and correlation evaluation between clinical and histological grading of acute and chronic (cutaneous) GvHD

From: Clinical versus histological grading in the assessment of cutaneous graft versus host disease

General statistics
Feature
Number of biopsies: N = 120
Kappa score evaluation Comparing features Kappa Weighted kappa
Histology versus clinical Revised histological aGvHD Revised clinical aGvHD 0.014 (poor) − 0.038 (very poor)
Revised histological cGvHD Revised clinical cGvHD 0.015 (poor) 0.0009 (poor)
Histology Revised histological aGvHD Original histological aGvHD grade 0.353 (fair) 0.391 (fair)
Revised histological cGvHD Original histological cGvHD grade Not possible (no original grades)
Clinical Revised clinical aGvHD Original clinical aGvHD grade 0.526 (moderate) 0.489 (moderate)
Revised clinical cGvHD (all tracts) Original clinical cGvHD grade (all tracts) 0.909 (very good) 0.829 (very good)
Correlation evaluation Comparing features p value   
Biopsies from all patients Revised histological score aGvHD Revised clinical aGvHD 0.6364   
Revised histological score cGvHD Revised clinical cGvHD overall 0.7843   
Revised histological score cGvHD Revised max. clinical cGvHD score skin 0.2382   
  Limited 0–50% skin involvement    
  Extensive > 50% skin involvement    
Biopsies from aGvHD patients Revised histological aGvHD Revised clinical aGvHD 0.3409   
Revised histological aGvHD Max. documented clinical aGvHD 0.3498   
Revised histological aGvHD Survival 0.0744   
Revised clinical GvHD Survival 0.9739   
Biopsies from cGvHD patients Revised histological cGvHD Revised clinical cGvHD overall 0.5105   
Revised histological cGvHD Revised clinical cGvHD skin 0.157   
  Limited 0–50% skin involvement    
  Extensive > 50% skin involvement    
Revised histological cGvHD Revised max. clinical cGvHD score skin 0.157   
  Limited 0–50% skin involvement    
  Extensive > 50% skin involvement    
Revised histological cGvHD Survival 0.4465   
Revised clinical cGvHD overall Survival 0.0002   
Revised max. clinical cGvHD score skin Survival 0.1249   
  Limited 0–50% skin involvement     
  Extensive > 50% skin involvement     
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