Clinical versus histological grading in the assessment of cutaneous graft versus host disease

Table 5 General statistics with kappa and correlation evaluation between clinical and histological grading of acute and chronic (cutaneous) GvHD

General statistics
Feature
Number of biopsies:			N = 120
Kappa score evaluation	Comparing features		Kappa	Weighted kappa
Histology versus clinical	Revised histological aGvHD	Revised clinical aGvHD	0.014 (poor)	− 0.038 (very poor)
Histology versus clinical	Revised histological cGvHD	Revised clinical cGvHD	0.015 (poor)	0.0009 (poor)
Histology	Revised histological aGvHD	Original histological aGvHD grade	0.353 (fair)	0.391 (fair)
Histology	Revised histological cGvHD	Original histological cGvHD grade	Not possible (no original grades)
Clinical	Revised clinical aGvHD	Original clinical aGvHD grade	0.526 (moderate)	0.489 (moderate)
Clinical	Revised clinical cGvHD (all tracts)	Original clinical cGvHD grade (all tracts)	0.909 (very good)	0.829 (very good)

Correlation evaluation	Comparing features		p value
Biopsies from all patients	Revised histological score aGvHD	Revised clinical aGvHD	0.6364
	Revised histological score cGvHD	Revised clinical cGvHD overall	0.7843
	Revised histological score cGvHD	Revised max. clinical cGvHD score skin	0.2382
		Limited 0–50% skin involvement
		Extensive > 50% skin involvement
Biopsies from aGvHD patients	Revised histological aGvHD	Revised clinical aGvHD	0.3409
	Revised histological aGvHD	Max. documented clinical aGvHD	0.3498
	Revised histological aGvHD	Survival	0.0744
	Revised clinical GvHD	Survival	0.9739
Biopsies from cGvHD patients	Revised histological cGvHD	Revised clinical cGvHD overall	0.5105
	Revised histological cGvHD	Revised clinical cGvHD skin	0.157
		Limited 0–50% skin involvement
		Extensive > 50% skin involvement
	Revised histological cGvHD	Revised max. clinical cGvHD score skin	0.157
		Limited 0–50% skin involvement
		Extensive > 50% skin involvement
	Revised histological cGvHD	Survival	0.4465
	Revised clinical cGvHD overall	Survival	0.0002
	Revised max. clinical cGvHD score skin	Survival	0.1249
	Limited 0–50% skin involvement
	Extensive > 50% skin involvement

ISSN: 2047-783X