Fig. 1
From: Dok-3 deficient mice display different immune clustering and Tim-3 expression
CD4+ T cells and CD8+ T cells proportion and the Tim-3 expression on these cells in two group mice. Spleen immune cells were isolated from 129 mice (n = 6) and Dok-3−/− mice (n = 6). a Flow cytometry (FCM) analysis of Tim-3 expression on CD4+ T cells marked by CD3+CD4+ (left), and the statistical graph was shown (right), CD4+ T cells (129, 38.73 ± 2.395; Dok-3−/−, 24.25 ± 1.596) and Tim-3 expression (129, 8.45 ± 1.568; Dok-3−/−, 16.21 ± 3.064). b Flow cytometry (FCM) analysis of Tim-3 expression on CD8+ T cells marked by CD3+CD8+ (left), and the statistical graph was shown (right), CD8+ T cells (129, 18.20 ± 1.857; Dok-3−/−, 12.35 ± 0.848) and Tim-3 expression (129, 12.68 ± 2.950; Dok-3−/−, 25.20 ± 2.595). Both the CD4+ T cells and CD8+ T cells’ gated strategy are shown in Additional file 1: Figure S1. *p < 0.05, **p < 0.01, ***p < 0.001