Fig. 4

Overexpression of miR-19b-3p alleviated LPS-induced inflammatory response of HUVECs. a MiR-19b-3p mimic transfection significantly increased the miR-19b-3p level, whereas miR-19b-3p inhibitor transfection further aggravated the reduced level of miR-19b-3p induced by LPS. b Overexpression of miR-19b-3p significantly weakened LPS-induced cell viability inhibition, while miR-19b-3p downregulation aggravated the inhibitory effect of LPS on cell viability. c, d miR-19b-3p overexpression reduced the levels of IL-6 and TNF-α induced by LPS treatment, whereas miR-19b-3p downregulation intensified the inductive effect of LPS on IL-6 and TNF-α. ***P < 0.001, compared with control group; ^#P < 0.05, ^###P < 0.001, compared with LPS group