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Table 4 Spectral characteristic of NDM-1 protein in the absence of any antibiotic and in the presence of streptomycin and amikacin antibiotics in single and in combination as well as in the presence of streptomycin and ciprofloxacin antibiotics in single and in combination

From: A mechanistic approach to prove the efficacy of combination therapy against New Delhi metallo-β-lactamases producing bacterial strain: a molecular and biochemical approach

 

MRE218 (deg cm2 dmol−1)

MRE222 (deg cm2 dmol−1)

% α helix at 222

NDM-1 only

− 13,153.0 ± 110

− 12,591.0 ± 95

33.83

NDM-1 + streptomycin (1:1)

− 23,502.9 ± 103

− 18,963.4 ± 106

54.86

NDM-1 + amikacin (1:1)

− 19,347.2 ± 112

− 16,495.8 ± 126

46.71

NDM-1 + streptomycin + amikacin (1:1:1)

− 19,032.8 ± 131

− 13,515.9 ± 101

36.88

NDM-1 + ciprofloxacin (1:1)

− 24,311.2 ± 117

− 21,951.4 ± 98

64.72

NDM-1 + streptomycin + ciprofloxacin (1:1:1)

− 18,885.6 ± 124

− 21,552.1 ± 105

63.40