Skip to main content

Table 4 Spectral characteristic of NDM-1 protein in the absence of any antibiotic and in the presence of streptomycin and amikacin antibiotics in single and in combination as well as in the presence of streptomycin and ciprofloxacin antibiotics in single and in combination

From: A mechanistic approach to prove the efficacy of combination therapy against New Delhi metallo-β-lactamases producing bacterial strain: a molecular and biochemical approach

 MRE218 (deg cm2 dmol−1)MRE222 (deg cm2 dmol−1)% α helix at 222
NDM-1 only− 13,153.0 ± 110− 12,591.0 ± 9533.83
NDM-1 + streptomycin (1:1)− 23,502.9 ± 103− 18,963.4 ± 10654.86
NDM-1 + amikacin (1:1)− 19,347.2 ± 112− 16,495.8 ± 12646.71
NDM-1 + streptomycin + amikacin (1:1:1)− 19,032.8 ± 131− 13,515.9 ± 10136.88
NDM-1 + ciprofloxacin (1:1)− 24,311.2 ± 117− 21,951.4 ± 9864.72
NDM-1 + streptomycin + ciprofloxacin (1:1:1)− 18,885.6 ± 124− 21,552.1 ± 10563.40