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Table 5 Binding parameters for interaction of NDM-1 with streptomycin, amikacin and ciprofloxacin

From: A mechanistic approach to prove the efficacy of combination therapy against New Delhi metallo-β-lactamases producing bacterial strain: a molecular and biochemical approach

Antibiotic

Temperature (K)

Ksv (M−1)

Ka (M−1)

n

R2

Streptomycin

298

4.4 × 104

7.74 × 101

0.435

0.992

303

1.4 × 104

1.99 × 1015

3.273

0.996

308

2.4 × 104

3.92 × 105

1.243

0.996

Amikacin

298

2.8 × 104

2.12 × 106

1.379

0.993

303

1.6 × 104

1.04 × 106

1.382

0.995

308

2.8 × 104

4.78 × 102

0.639

0.994

Ciprofloxacin

298

4.8 × 104

4.48 × 107

1.604

0.994

303

2.8 × 104

2.77 × 104

1.012

0.996

308

4.0 × 104

1.45 × 109

1.930

0.997