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Table 5 Binding parameters for interaction of NDM-1 with streptomycin, amikacin and ciprofloxacin

From: A mechanistic approach to prove the efficacy of combination therapy against New Delhi metallo-β-lactamases producing bacterial strain: a molecular and biochemical approach

AntibioticTemperature (K)Ksv (M−1)Ka (M−1)nR2
Streptomycin2984.4 × 1047.74 × 1010.4350.992
3031.4 × 1041.99 × 10153.2730.996
3082.4 × 1043.92 × 1051.2430.996
Amikacin2982.8 × 1042.12 × 1061.3790.993
3031.6 × 1041.04 × 1061.3820.995
3082.8 × 1044.78 × 1020.6390.994
Ciprofloxacin2984.8 × 1044.48 × 1071.6040.994
3032.8 × 1042.77 × 1041.0120.996
3084.0 × 1041.45 × 1091.9300.997