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Table 6 Thermodynamic parameters for interaction of NDM-1 with streptomycin, amikacin and ciprofloxacin

From: A mechanistic approach to prove the efficacy of combination therapy against New Delhi metallo-β-lactamases producing bacterial strain: a molecular and biochemical approach

AntibioticTemperature (K)ΔH (Jmol−1)ΔS (J K−1mol−1)TΔS (kJ mol−1)ΔG (kJ mol−1)
Streptomycin298670.440 ± 0.52385.681 ± 0.8710.932 ± 0.7− 10.861 ± 1.2
303  722.861 ± 1.0− 88.739 ± 1.7
308  734.789 ± 1.3− 32.979 ± 1.4
Amikacin298− 637.766 ± 0.6− 2008.662 ± 1.2− 598.581 ± 0.3− 36.088 ± 1.5
303  − 608.624 ± 0.8− 34.900 ± 1.1
308  − 618.667 ± 1.6− 15.797 ± 0.9
Ciprofloxacin298257.657 ± 0.7986.040 ± 1.4293.839 ± 0.8− 43.647 ± 0.9
303  298.770 ± 1.1− 25.768 ± 1.5
308  303.700 ± 1.8− 54.015 ± 1.3