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Table 6 Thermodynamic parameters for interaction of NDM-1 with streptomycin, amikacin and ciprofloxacin

From: A mechanistic approach to prove the efficacy of combination therapy against New Delhi metallo-β-lactamases producing bacterial strain: a molecular and biochemical approach

Antibiotic

Temperature (K)

ΔH (Jmol−1)

ΔS (J K−1mol−1)

TΔS (kJ mol−1)

ΔG (kJ mol−1)

Streptomycin

298

670.440 ± 0.5

2385.681 ± 0.8

710.932 ± 0.7

− 10.861 ± 1.2

303

  

722.861 ± 1.0

− 88.739 ± 1.7

308

  

734.789 ± 1.3

− 32.979 ± 1.4

Amikacin

298

− 637.766 ± 0.6

− 2008.662 ± 1.2

− 598.581 ± 0.3

− 36.088 ± 1.5

303

  

− 608.624 ± 0.8

− 34.900 ± 1.1

308

  

− 618.667 ± 1.6

− 15.797 ± 0.9

Ciprofloxacin

298

257.657 ± 0.7

986.040 ± 1.4

293.839 ± 0.8

− 43.647 ± 0.9

303

  

298.770 ± 1.1

− 25.768 ± 1.5

308

  

303.700 ± 1.8

− 54.015 ± 1.3