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Table 5 Pooled proportions of the different pregnancy and perinatal outcomes identified in the present systematic review

From: The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal–fetal transmission: a systematic review and meta-analysis

Pregnancy outcome SARS-CoV-2 MERS-CoV SARS-CoV
Study (n) Reports (n) Pregnancies or neonate (n) Pooled  % (95%-CI) Study (n) Reports (n) Pregnancies or neonate (n) Pooled  % (95%-CI) Study (n) Reports (n) Pregnancies or neonate (n) Pooled  % (95%-CI)
PTB < 34 week 11 61 682 8.9% [6.1–19.3] 7 4 12 33.3% [14.2–38.9] 7 3 25 12% [3.6–31.5]
PTB < 37 week 9 86 602 14.3% [9.2–33.2] 7 0 12 0.0% [0.0–7.4] 6 5 23 21.7% [7.4–44.6]
>37 week 13 317 686 46.2% [41.5–58.9] 5 8 10 80% [44.2–97.8] 7 5 13 38.5% [0.0–68.4]
Preeclampsia 5 9 159 5.7% [3.3–10.1] 2 1 8 12.5% [0.0–53.6] 2 0 2 0% [0.0–84.7]
pPROM 7 16 179 8.9% [5.5–14.6] 2 0 2 0.0 [0.0–84.2] 2 1 8 12.5% [0.0–53.8]
FGR 4 1 86 1.2% [0.0–6.3] 4 0 6 0.0% [0.0–46.5] 6 2 16 12.5% [2.2–38.6]
Miscarriage 2 1 41 2.4% [0.0–13.5] 2 8 21 38.1% [18.7–62.5]
ICU admission 25 53 186 28.5%23.1–54.4] 2 1 3 33.3% [1.2–91.3] 2 12 22 54.5% [32.1–76.8]
Maternal death 4 8 523 1.5% [1.2–9.6] 4 4 10 40% [12.5–74.3] 3 3 24 12.5% [3.3–32.9]
Cesarean delivery 19 426 747 57.0% [48.9–78.8] 6 6 9 66.7% [30.2–93.5] 6 8 16 50% [25.6–75.9]
Normal delivery 11 192 662 29.0% [21.4–33.5] 2 2 12 16.7% [2.4–48.6] 4 4 18 22.2% [6.6–48.7]
Perinatal outcome
 Fetal distress 7 14 56 25% [14.4–39.6] 5 0 0 0.0% [0.0–52.3] 5 4 12 33.3% [10.1–65.2]
 Apgar score < 7 7 1 72 1.4% [0.0–7.8] 4 0 4 0.0% [0.0–60.1] 5 0 5 0.0% [0.0–52.3]
 Neonatal asphyxia 4 1 64 1.6% [0.0–8.9] 3 0 3 0.0% [0.0–71.4] 4 0 4 0.0% [0.060.8]
 Admission to NICU 4 8 69 11.6% [5.4–22.6] 3 1 3 33.3% [1.3–84.5] 1 0 1 0.0% [0.0–98.5]
 Perinatal death 8 5 430 1.2% [1.0–8.7] 7 4 12 33.3% [10.6–65.3] 6 1 10 10% [0.0–45.3]
 Vertical transmission 25 0 1271 0.0 [0.0–1.5] 7 0 12 0.0% [0.0–26.5] 7 0 7 0.0% [0.0–41.6]
  1. PTB preterm birth, pPROM preterm premature rupture of membranes, FGR fetal growth restriction, ICU intensive care unit, NICU neonatal intensive care unit