|
Pregnancy outcome
|
SARS-CoV-2
|
MERS-CoV
|
SARS-CoV
|
|---|
|
Study (n)
|
Reports (n)
|
Pregnancies or neonate (n)
|
Pooled % (95%-CI)
|
Study (n)
|
Reports (n)
|
Pregnancies or neonate (n)
|
Pooled % (95%-CI)
|
Study (n)
|
Reports (n)
|
Pregnancies or neonate (n)
|
Pooled % (95%-CI)
|
|---|
|
PTB < 34 week
|
11
|
61
|
682
|
8.9% [6.1–19.3]
|
7
|
4
|
12
|
33.3% [14.2–38.9]
|
7
|
3
|
25
|
12% [3.6–31.5]
|
|
PTB < 37 week
|
9
|
86
|
602
|
14.3% [9.2–33.2]
|
7
|
0
|
12
|
0.0% [0.0–7.4]
|
6
|
5
|
23
|
21.7% [7.4–44.6]
|
|
>37 week
|
13
|
317
|
686
|
46.2% [41.5–58.9]
|
5
|
8
|
10
|
80% [44.2–97.8]
|
7
|
5
|
13
|
38.5% [0.0–68.4]
|
|
Preeclampsia
|
5
|
9
|
159
|
5.7% [3.3–10.1]
|
2
|
1
|
8
|
12.5% [0.0–53.6]
|
2
|
0
|
2
|
0% [0.0–84.7]
|
|
pPROM
|
7
|
16
|
179
|
8.9% [5.5–14.6]
|
2
|
0
|
2
|
0.0 [0.0–84.2]
|
2
|
1
|
8
|
12.5% [0.0–53.8]
|
|
FGR
|
4
|
1
|
86
|
1.2% [0.0–6.3]
|
4
|
0
|
6
|
0.0% [0.0–46.5]
|
6
|
2
|
16
|
12.5% [2.2–38.6]
|
|
Miscarriage
|
2
|
1
|
41
|
2.4% [0.0–13.5]
|
–
|
–
|
–
|
–
|
2
|
8
|
21
|
38.1% [18.7–62.5]
|
|
ICU admission
|
25
|
53
|
186
|
28.5%23.1–54.4]
|
2
|
1
|
3
|
33.3% [1.2–91.3]
|
2
|
12
|
22
|
54.5% [32.1–76.8]
|
|
Maternal death
|
4
|
8
|
523
|
1.5% [1.2–9.6]
|
4
|
4
|
10
|
40% [12.5–74.3]
|
3
|
3
|
24
|
12.5% [3.3–32.9]
|
|
Cesarean delivery
|
19
|
426
|
747
|
57.0% [48.9–78.8]
|
6
|
6
|
9
|
66.7% [30.2–93.5]
|
6
|
8
|
16
|
50% [25.6–75.9]
|
|
Normal delivery
|
11
|
192
|
662
|
29.0% [21.4–33.5]
|
2
|
2
|
12
|
16.7% [2.4–48.6]
|
4
|
4
|
18
|
22.2% [6.6–48.7]
|
|
Perinatal outcome
|
|
Fetal distress
|
7
|
14
|
56
|
25% [14.4–39.6]
|
5
|
0
|
0
|
0.0% [0.0–52.3]
|
5
|
4
|
12
|
33.3% [10.1–65.2]
|
|
Apgar score < 7
|
7
|
1
|
72
|
1.4% [0.0–7.8]
|
4
|
0
|
4
|
0.0% [0.0–60.1]
|
5
|
0
|
5
|
0.0% [0.0–52.3]
|
|
Neonatal asphyxia
|
4
|
1
|
64
|
1.6% [0.0–8.9]
|
3
|
0
|
3
|
0.0% [0.0–71.4]
|
4
|
0
|
4
|
0.0% [0.060.8]
|
|
Admission to NICU
|
4
|
8
|
69
|
11.6% [5.4–22.6]
|
3
|
1
|
3
|
33.3% [1.3–84.5]
|
1
|
0
|
1
|
0.0% [0.0–98.5]
|
|
Perinatal death
|
8
|
5
|
430
|
1.2% [1.0–8.7]
|
7
|
4
|
12
|
33.3% [10.6–65.3]
|
6
|
1
|
10
|
10% [0.0–45.3]
|
|
Vertical transmission
|
25
|
0
|
1271
|
0.0 [0.0–1.5]
|
7
|
0
|
12
|
0.0% [0.0–26.5]
|
7
|
0
|
7
|
0.0% [0.0–41.6]
|
- PTB preterm birth, pPROM preterm premature rupture of membranes, FGR fetal growth restriction, ICU intensive care unit, NICU neonatal intensive care unit
