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Table 2 Characteristics of patients with 1 comorbidity or ≥ 2 comorbidities

From: Development of a quantitative segmentation model to assess the effect of comorbidity on patients with COVID-19

Variables Without comorbidity (n = 242) 1 comorbidity (n = 38)  ≥ 2 comorbidities (n = 14) P1 value P2 value
Gender     0.126 0.734
 Male 127 (52.5%) 13 (34.2%) 6 (42.9%)   
 Female 115 (47.5%) 25 (65.8%) 8 (57.1%)   
Age (years) 44.00 (32.00–53.00) 53.00 (47.00–61.00) 60.00 (52.00–67.00) 0.000 0.000
Incubation period (days) 3.00 (2.00–7.00) 6.00 (4.00–7.00) 8.00 (3.00–13.00) 0.029 0.041
Symptoms      
 Fever 223 (92.2%) 38 (100%) 14 (100%) 0.149 0.572
 Dyspnea 129 (53.3%) 29 (76.3%) 12 (85.7%) 0.008 0.065
 More than one symptom 178 (73.6%) 35 (92.1%) 12 (85.7%) 0.479 0.486
CRP abnormal     0.021 0.072
 Yes 130 (53.7%) 28 (73.7%) 11 (78.6%)   
 No 112 (46.3%) 10 (26.3%) 3 (21.4%)   
WBC abnormal     0.138 0.064
 Yes 45 (18.6%) 11 (28.9%) 6 (42.9%)   
 No 197 (81.4%) 27 (71.1%) 8 (57.1%)   
LY count (× 109/L) 0.72 (0.51–1.12) 0.64 (0.39–0.94) 0.45 (0.27–0.89) 0.043 0.036
Severity status     0.000 0.000
 Yes 16 (6.6%) 14 (36.8%) 8 (57.1%)   
 No 226 (93.4%) 22 (42.3%) 6 (42.9%)   
Quantitative CT analysis      
 LUV (cm3) 3709.28 (2939.74–4538.04) 3885.28 (2846.22–4916.78) 4170.63 (3129.45–4697.75) 0.606 0.252
 LEV (cm3) 127.82 (50.50–265.91) 235.87 (85.14–629.24) 237.17 (161.81–837.53) 0.001 0.009
 LEV/LUV 0.04 (0.01–0.08) 0.07 (0.02–0.15) 0.09 (0.04–0.27) 0.001 0.017
 COV (cm3) 40.45 (11.82–96.27) 97.89 (23.65–200.86) 94.86 (24.80–289.90) 0.001 0.022
 COV/LUV 0.01 (0.00–0.03) 0.03 (0.01–0.06) 0.04 (0.01–0.11) 0.001 0.046
 GGOV (cm3) 74.71 (31.08–150.72) 135.80 (49.43–281.20) 197.58 (66.95–377.93) 0.003 0.006
 GGOV /LUV 0.02 (0.01–0.04) 0.03 (0.02–0.10) 0.05 (0.02–0.15) 0.003 0.013
 LEN 19.00 (10.00–37.25) 31.00 (20.00–46.00) 30.00 (23.00–32.00) 0.001 0.202
  1. CRP: C reactive protein; WBC: white blood cell count; LY: lymphocyte; LUV: the volume of the whole lung; LEV: the volume of lesion; COV: the volume of consolidation; GGOV: the volume of GGO; LEN: the number of lesions
  2. P1 value: 1 comorbidity vs. without comorbidity; P2 value: ≥ 2 comorbidities vs. without comorbidity; P values written in italics indicate a significant difference