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Table 3 Characteristics of patients with different comorbidities

From: Development of a quantitative segmentation model to assess the effect of comorbidity on patients with COVID-19

Variables Without comorbidity (n = 242) Hypertension (n = 22) Diabetes mellitus (n = 7) Hepatitis B infection (n = 8) P1 value P2 value P3 value
Gender      0.552 0.544 0.111
 Male 127 (52.5%) 13 (59.1%) 5 (71.4%) 7 (87.5%)    
 Female 115 (47.5%) 9 (40.9%) 2 (28.6%) 1 (12.5%)    
Age (years) 44.00 (32.00–53.00) 56.00 (48.50–62.25) 51.00 (43.00–69.00) 46.00 (43.00–52.00) 0.000 0.055 0.315
Incubation period (days) 3.00 (2.00–7.00) 6.50 (4.00–7.25) 6.00 (5.00–7.00) 4.00 (2.25–6.50) 0.076 0.208 0.835
Symptoms        
 Fever 223 (92.2%) 22 (100%) 7 (100%) 8 (100%) 0.351 1.000 1.000
 Dyspnea 129 (53.3%) 19 (86.4%) 6 (85.7%) 4 (50.0%) 0.003 0.190 1.000
 More than one symptom 178 (73.6%) 21 (95.5%) 6 (85.7%) 6 (75.0%) 0.022 0.775 1.000
CRP abnormal      0.003 1.000 0.586
 Yes 130 (53.7%) 19 (86.4%) 4 (57.1%) 3 (37.5%)    
 No 112 (46.3%) 3 (13.6%) 3 (42.9%) 5 (62.5%)    
WBC abnormal      0.773 0.041 0.379
 Yes 45 (18.6%) 3 (13.6%) 4 (57.1%) 3 (37.5%)    
 No 197 (81.4%) 19 (86.4%) 3 (42.9%) 5 (62.5%)    
LY count (× 109/L) 0.72 (0.51–1.12) 0.60 (0.31–0.89) 0.69 (0.56–1.10) 0.56 (0.35–0.94) 0.044 0.977 0.039
Severity status      0.000 0.000 0.010
 Yes 16 (6.6%) 7 (31.8%) 3 (42.9%) 3 (37.5%)    
 No 226 (93.4%) 15 (68.2%) 4 (57.1%) 5 (62.5%)    
Pleural effusion      1.000 0.859 0.935
 Yes 13 (5.4%) 1 (4.5%) 1 (14.3%) 1 (12.5%)    
 No 229 (94.6%) 21 (95.5%) 6 (85.7%) 7 (87.5%)    
Quantitative CT analysis        
 LUV (cm3) 3709.28 (2939.74–4538.04) 3279.78 (2647.81–4775.08) 4289.78 (3043.78–5644.50) 4457.41 (2895.61–5104.92) 0.545 0.400 0.393
 LEV (cm3) 127.82 (50.50–265.91) 192.55 (68.09–581.92) 570.00 (206.43–1365.34) 187.85 (76.33–361.09) 0.036 0.001 0.315
 LEV/LUV 0.04 (0.01–0.08) 0.05 (0.02–0.15) 0.17 (0.05–0.26) 0.04 (0.02–0.09) 0.033 0.001 0.429
 COV (cm3) 40.45 (11.82–96.27) 74.24 (21.58–212.75) 178.87 (119.98–605.27) 67.43 (21.00–168.81) 0.039 0.001 0.345
 COV/LUV 0.01 (0.00–0.03) 0.02 (0.01–0.06) 0.04 (0.03–0.11) 0.02 (0.00–0.05) 0.045 0.001 0.390
 GGOV (cm3) 74.71 (31.08–150.72) 104.19 (46.51–212.08) 369.13 (66.95–765.53) 82.82 (48.20–169.62) 0.075 0.004 0.471
 GGOV/LUV 0.02 (0.01–0.04) 0.03 (0.02–0.08) 0.10 (0.02–0.15) 0.02 (0.01–0.04) 0.047 0.003 0.590
 LEN 19.00 (10.00–37.25) 37.00 (20.00–46.25) 37.00 (22.00–46.00) 24.50 (16.75–45.25) 0.004 0.068 0.190
  1. CRP: C reactive protein; WBC: white blood cell count; LY: lymphocyte; LUV: the volume of the whole lung; LEV: the volume of lesion; COV: the volume of consolidation; GGOV: the volume of GGO; LEN: the number of lesions
  2. P1 value: hypertension vs. without comorbidity; P2 value: diabetes mellitus vs. without comorbidity; P3 value: hepatitis B infection vs. without comorbidity; P values written in italics indicate a significant difference