From: Extended liver resection in mice: state of the art and pitfalls—a systematic review
Year | Work-group | Publication | Resection method | Duration of the intervention (min) | Anesthesia | Mouse | Extent of the liver resection (%) | Mortality | Observation time | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Strain | Age (w) | Weight (g) | |||||||||
1953 | Yokoyoma et al | Regeneration of mouse liver after partial hepatectomy | Suture ligature of left and medial lobe (Brues, Drury, and Brues) | – | Ether | Strain A white | 13 | 24–27,5 | 65 | – | 3/4, 1, 2, 3, 4, 5, 6, 7, 8, 10, 14, 21, 28, 38–45 days 2, 4, 6 m |
2004 | Nikfarjam et al | A model of partial hepatectomy in mice | Hemostatic clip | – | Ketamine/ Xylazine + Carprofen | CBA | 8–10 | 20–25 | 70 | 2% | 21 days |
2004 | Garbow et al | MRI measurement of liver regeneration in mice following partial hepatectomy | Suture ligature of left lateral lobe Suture ligature of right median lobe Suture ligature of left median lobe | 20–25 | Isoflurane | – | – | – | 67 | – | – |
2006 | Inderbitzin et al | Regenerative capacity of individual liver lobes in the microsurgical mouse model | – | – | – | BALB/c | 6–8 | 20–25 | 75 | – | 24, 48 h |
2008 | Mitchell et al | A reproducible and well–tolerated method for 2/3 partial hepatectomy in mice | Two Suture ligature | – | Isoflurane + Buprenorphine | – | 8–14 | – | 67 | – | – |
2008 | Boyce et al | A detailed methodology of partial hepatectomy in the mouse | Suture ligature | – | Isoflurane + Buprenorphine | – | – | – | 70 | 4% | – |
2008 | Martins et al | Hepatic lobectomy and segmentectomy models using microsurgical techniques | Microscope assisted Catheter-guided Ligature | 15 | – | – | – | – | 70 | – | – |
2009 | Sorg et al | Consequences of surgical stress on the kinetics of skin wound healing: partial hepatectomy delays and functionally alters dermal repair | Suture ligature of right upper left upper and left lower lobe | – | Ketamine/Xylazine | SKH1-hr | 8–12 | 35–45 | 70 | 0% | 10 days |
2010 | Zhang et al | The benefits of ligating the lobar portal triads before partial hepatectomy in the mouse | Ligature of the lobar portal triads + Suture ligature of left lateral lobe and median lobes | 15–20 | Isoflurane + Bupivacaine | C57BL/6 | 8–12 | 20–25 | 70 | 1% | 7d |
2011 | Hori et al | Simple and sure methodology for massive hepatectomy in the mouse | Suture ligature Hemostatic Clip Electrocautery scalpels | Suture: 30 Clip: 10 | Isoflurane + Buprenorphine | C57BL/6 | 10–20 | 25 | > 70 | 50% | 180 h |
2012 | Bonninghof et al | Effect of different liver resection methods on liver damage and regeneration factors VEGF and FGF-2 in mice | Suture Ligature | – | Ketamine/ Xylazine + Buprenorphine | BALB/c | 8–10 | 20–25 | 50 and 70 | 2% | 10 min 3, 24, 48, 120, 240 h |
2012 | Hori et al | Simple and reproducible hepatectomy in the mouse using the clip technique | Suture ligature Hemostatic clip | Suture: 30 Clip: 10 | Isoflurane + Buprenorphine | C57BL/6 | 10–20 | 25 | 75 and 80 | 75% resection: 40% 80% resection: 90% | 180 h |
2014 | Xie et al | Monitoring of systemic and hepatic hemodynamic parameters in mice | – | – | – | – | – | – | – | – | – |
2015 | Nevzorova et al | Partial hepatectomy in mice | Suture ligature of left lateral lobe and left portion of the median lobe | – | Ketamine/xylazine and isoflurane | – | 8–14 | 5% | 0.5, 2, 4, 6 h | ||
2016 | Forbes et al | Liver regeneration—mechanisms and models to clinical application | – | – | – | – | – | – | – | – | – |
2016 | Orsini et al | MRI as Primary End Point for Pharmacologic Experiments of Liver Regeneration in a Murine Model of Partial Hepatectomy | Suture ligature of left lobe and median lobe | 30 | Isoflurane + Buprenorphine | C57BL/6 J | 12–14 | – | – | 4 days | |
2016 | Xu et al | A reliable scoring system after major liver resection in mice | Suture ligature of left lateral lobe and median lobe | – | Isoflurane + Buprenorphine | C57BL/6 | 10–12 | 19–23 | 65,30 | 24 h: 19% 2d: 28% 3d: 30% 4d: 33% 7d: 33% | 6, 12, 24 h 2, 3, 5, 7 days |
2016 | Young et al | Metabolic scaling predicts post-hepatectomy liver regeneration after accounting for hepatocyte hypertrophy | – | – | – | – | 8–12 | 68 | – | 0, 12, 24, 36, 48, 60, 72, 96 h | |
2016 | Xie et al | Quantification of Hepatic Vascular and Parenchymal Regeneration in Mice | – | – | – | – | – | – | – | – | – |
2017 | Will et al | Longitudinal micro-computed tomography monitoring of progressive liver regeneration in a mouse model of partial hepatectomy | Suture ligature of upper left posterior and left anterior lobe | – | – | C57BL/6 N | 11–12 | 18–26 | 42 | – | 1, 2, 3, 7 days |
2018 | Ozawa et al | Evaluation of safety for hepatectomy in a novel mouse model with non-alcoholic steatohepatitis | Single suture ligature of left and middle lobe | – | Ether | C57BL/6 J | 6 | – | 70 | 0% | 6, 12 h |
Ø 11 | Ø 23 |