Skip to main content

Table 1 Overview of the revised articles

From: Extended liver resection in mice: state of the art and pitfalls—a systematic review

Year

Work-group

Publication

Resection method

Duration of the intervention (min)

Anesthesia

Mouse

Extent of the liver resection (%)

Mortality

Observation time

Strain

Age (w)

Weight (g)

1953

Yokoyoma et al

Regeneration of mouse liver after partial hepatectomy

Suture ligature of left and medial lobe (Brues, Drury, and Brues)

Ether

Strain A white

13

24–27,5

65

3/4, 1, 2, 3, 4, 5, 6, 7, 8, 10, 14, 21, 28, 38–45 days

2, 4, 6 m

2004

Nikfarjam et al

A model of partial hepatectomy in mice

Hemostatic clip

Ketamine/ Xylazine + Carprofen

CBA

8–10

20–25

70

2%

21 days

2004

Garbow et al

MRI measurement of liver regeneration in mice following partial hepatectomy

Suture ligature of left lateral lobe

Suture ligature of right median lobe

Suture ligature of left median lobe

20–25

Isoflurane

67

2006

Inderbitzin et al

Regenerative capacity of individual liver lobes in the microsurgical mouse model

BALB/c

6–8

20–25

75

24, 48 h

2008

Mitchell et al

A reproducible and well–tolerated method for 2/3 partial hepatectomy in mice

Two Suture ligature

Isoflurane + Buprenorphine

8–14

67

2008

Boyce et al

A detailed methodology of partial hepatectomy in the mouse

Suture ligature

Isoflurane + Buprenorphine

70

4%

2008

Martins et al

Hepatic lobectomy and segmentectomy models using microsurgical techniques

Microscope assisted

Catheter-guided Ligature

15

70

2009

Sorg et al

Consequences of surgical stress on the kinetics of skin wound healing: partial hepatectomy delays and functionally alters dermal repair

Suture ligature of right upper left upper and left lower lobe

Ketamine/Xylazine

SKH1-hr

8–12

35–45

70

0%

10 days

2010

Zhang et al

The benefits of ligating the lobar portal triads before partial hepatectomy in the mouse

Ligature of the lobar portal triads + Suture ligature of left lateral lobe and median lobes

15–20

Isoflurane + Bupivacaine

C57BL/6

8–12

20–25

70

1%

7d

2011

Hori et al

Simple and sure methodology for massive hepatectomy in the mouse

Suture ligature

Hemostatic Clip

Electrocautery scalpels

Suture: 30

Clip: 10

Isoflurane + Buprenorphine

C57BL/6

10–20

25

 > 70

50%

180 h

2012

Bonninghof et al

Effect of different liver resection methods on liver damage and regeneration factors VEGF and FGF-2 in mice

Suture Ligature

Ketamine/ Xylazine + Buprenorphine

BALB/c

8–10

20–25

50 and 70

2%

10 min

3, 24, 48, 120, 240 h

2012

Hori et al

Simple and reproducible hepatectomy in the mouse using the clip technique

Suture ligature

Hemostatic clip

Suture: 30

Clip: 10

Isoflurane + Buprenorphine

C57BL/6

10–20

25

75 and 80

75% resection: 40%

80% resection: 90%

180 h

2014

Xie et al

Monitoring of systemic and hepatic hemodynamic parameters in mice

2015

Nevzorova et al

Partial hepatectomy in mice

Suture ligature of left lateral lobe and left portion of the median lobe

Ketamine/xylazine and isoflurane

8–14

  

5%

0.5, 2, 4, 6 h

2016

Forbes et al

Liver regeneration—mechanisms and models to clinical application

2016

Orsini et al

MRI as Primary End Point for Pharmacologic Experiments of Liver Regeneration in a Murine Model of Partial Hepatectomy

Suture ligature of left lobe and median lobe

30

Isoflurane + Buprenorphine

C57BL/6 J

12–14

 

4 days

2016

Xu et al

A reliable scoring system after major liver resection in mice

Suture ligature of left lateral lobe and median lobe

Isoflurane + Buprenorphine

C57BL/6

10–12

19–23

65,30

24 h: 19%

2d: 28%

3d: 30%

4d: 33%

7d: 33%

6, 12, 24 h

2, 3, 5, 7 days

2016

Young et al

Metabolic scaling predicts post-hepatectomy liver regeneration after accounting for hepatocyte hypertrophy

8–12

 

68

0, 12, 24, 36, 48, 60, 72, 96 h

2016

Xie et al

Quantification of Hepatic Vascular and Parenchymal Regeneration in Mice

2017

Will et al

Longitudinal micro-computed tomography monitoring of progressive liver regeneration in a mouse model of partial hepatectomy

Suture ligature of upper left posterior and left anterior lobe

C57BL/6 N

11–12

18–26

42

1, 2, 3, 7 days

2018

Ozawa et al

Evaluation of safety for hepatectomy in a novel mouse model with non-alcoholic steatohepatitis

Single suture ligature of left and middle lobe

Ether

C57BL/6 J

6

70

0%

6, 12 h

       

Ø 11

Ø 23

   
  1. A systematic search was conducted using Pubmed, gathering publications, which engaged with the mouse model of extended liver resection as a method itself. The results of this search were filtered according to their language, novelty, and relevancy. The Boolean search found 3741 articles on Pubmed, with 3130 publications remaining when filtered by language and the presence of a full text. In total, 21 of these publications examined the critical themes of the animal model described