Fig. 5
From: LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2/ARE axis
Nfr2 activator partially blocks the promotion effect of lncRNA NEAT1 in matrix degradation. a Nrf2 expression in control and Nfr2 activator (TBHQ) groups. b The effect of lncRNA NEAT1 with or without Nfr2 activator on nucleus pulposus cell proliferation evaluated by CCK-8 assay. c The effect of lncRNA NEAT1 with or without Nfr2 activator on mRNA expression of Col II, Aggrecan, MMP-3 and MMP-13 evaluated by RT-PCR. d The effect of lncRNA NEAT1 with or without Nfr2 activator on protein expression of Col II, Aggrecan, MMP-3 and MMP-13 evaluated by Western blot assay. *p < 0.05