EuroScore and IL-6 predict the course in ICU after cardiac surgery

Table 4 Investigation of possible predictors for duration of stay in ICU after surgery

Variable	Category	Univariable model			Multivariable model
Variable	Category	OR	95% CI	p value^j	OR	95% CI	p value^j
Age [years]^a	Linear	1.02	[1.01, 1.03]	< 0.001	1.01	[1.00, 1.02]	0.02
Sex^b	Male	1	[1.00, 1.00]	0.6	1	[1.00, 1.00]	0.8
	Female	1.04	[0.89, 1.22]	0.6	1.03	[0.85, 1.24]	0.8
EF [%]^c	≤ 45	1	[1.00, 1.00]	< 0.001	1	[1.00, 1.00]	0.001
	46–64	0.56	[0.45, 0.70]		0.71	[0.56, 0.90]
	≥ 65	0.53	[0.44, 0.63]		0.68	[0.56, 0.84]
EuroScore^d	0–2	1	[1.00, 1.00]	< 0.001	1	[1.00, 1.00]	< 0.001
	3–5	1.37	[1.14, 1.66]		1.29	[1.03, 1.61]
	> 6	2.61	[2.14, 3.18]		1.97	[1.50, 2.59]
Creatinine [mg/dl]^e	< 1.2	1	[1.00, 1.00]	< 0.001	1	[1.00, 1.00]	< 0.001
	1.2–2.1	1.76	[1.50, 2.07]		1.56	[1.31, 1.86]
	> 2.1	2.5	[1.64, 3.80]		1.71	[1.07, 2.72]
IL-6 [pg/ml]^f	Q1 (< 102)	1	[1.00, 1.00]	0.2	1	[1.00, 1.00]	0.009
	Q2 (102–165)	1.18	[0.94, 1.48]		1.41	[1.10, 1.81]
	Q3 (166–256)	1.17	[0.93, 1.47]		1.3	[1.01, 1.67]
	Q4 (257–421)	1.12	[0.89, 1.41]		1.31	[1.01, 1.70]
	Q5 (> 421)	1.33	[1.05, 1.67]		1.6	[1.23, 2.07]
CPB [min]^g	Q1 (< 72)	1	[1.00, 1.00]	< 0.001	1	[1.00, 1.00]	< 0.001
	Q2 (72–85)	1.18	[0.93, 1.48]		1.15	[0.90, 1.47]
	Q3 (86–100)	0.99	[0.78, 1.25]		0.9	[0.70, 1.16]
	Q4 (101–124)	1.2	[0.95, 1.51]		1.04	[0.81, 1.33]
	Q5 (> 124)	2.29	[1.82, 2.89]		1.92	[1.47, 2.50]
Operation^h	CABG	1	[1.00, 1.00]	< 0.001	1	[1.00, 1.00]	0.02
	AV	0.84	[0.70, 1.00]		0.89	[0.73, 1.08]
	CABG + AV	1.17	[0.93, 1.47]		0.89	[0.67, 1.17]
	MV	1.29	[0.99, 1.67]		1.28	[0.95, 1.72]
	MV + TV	3.67	[1.98, 6.81]		2.19	[1.09, 4.36]

Logistic regression model investigating possible predictors for duration of stay in ICU. Baseline are patients being dismissed from ICU ≤ 2 days (compared to patients with being hospitalized on ICU > 2 days). The univariable model is shown on the left, the multivariable model on the right
^aAge is analysed as linear variable
^bThe reference category are males
^cEjection fraction (EF) displayed in quintiles (resulting in 3 groups), reference category are values ≤ 45
^dEuroScore analysed in three groups according to guidelines: mild/moderate/severe risk. The reference category is the lowest score
^eCreatinine displayed in three groups. The reference category are lowest values
^fIL-6 is displayed in Q (quintiles). The reference category is the first quintile
^gCPB is displayed in Q (quintiles). The reference category is the first quintile
^hReference category is CABG
^jp value: from likelihood ratio test
OR odds ratio, CI confidence interval, EF ejection fraction, CPB cardiopulmonary bypass, CABG coronary artery bypass grafting, AV aortic valve surgery, CABG + AV combined operation of aortic valve and coronary artery bypass grafting, MV mitral valve surgery, MV + TV combined operation of mitral and tricuspid valve

ISSN: 2047-783X