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Table 3 Factors associated with Treatment failure of 262 patients with M/XDR-TB

From: Treatment outcomes of patients with multidrug and extensively drug-resistant tuberculosis in Zhejiang, China

Chracteristic

Treatment successc

Treatment failure

Total

Univariate analysis

Multivariate analysis

Cure, TC n(%)

Failure (n,%)

N (%)

OR (95% CI)d

P

OR (95% CI)

P

Sex

 Male

105

54.69

42

21.88

192

73.28

1.25(0.656–2.383)

0.498

0.66(0.109–4.011)

0.652

 Female

40

57.14

20

28.57

70

26.72

1

 

1

 

Age

          

  < 60 year

124

62.94

35

17.77

197

75.19

4.555(2.302–9.015)

0.000

9.053(1.606–51.027)

0.013

  ≥ 60 year

21

32.31

27

41.54

65

24.81

1

 

1

 

Occupationa

          

 Farmer

108

54.82

47

23.86

197

75.19

0.932(0.467–1.859)

0.841

1.343(0.262–6.898)

0.724

 Others

37

56.92

15

23.08

65

24.81

1

 

1

 

Family registerb

          

 Resident

62

50

38

30.65

124

47.33

0.472(0.257–0.866)

0.015

5.502(0.778–38.935)

0.088

 Floating

83

60.14

24

17.39

138

52.67

1

 

1

 

Previous TB treatment

          

 No

14

66.67

4

19.05

21

8.02

1.55(0.489–4.911)

0.457

2.033(0.113–36.662)

0.631

 Yes

131

54.36

58

24.07

241

91.98

1

 

1

 

Weight

          

  < 50 kg

19

44.19

16

37.21

43

16.41

2.824(1.198–6.657)

0.018

8.668(1.679–44.756)

0.01

  >  = 50 kg

57

64.04

17

19.1

89

33.97

1

 

1

 

TB symptoms

          

Hemoptysis

        

 Yes

105

58.01

38

20.99

181

69.08

0.603(0.322–1.129)

0.114

8.928(1.048–76.923)

0.045

 No

40

49.38

24

29.63

81

30.92

1

 

1

 

Cavitary

          

 Yes

42

33.07

42

33.07

127

48.47

5.154(2.71–9.803)

0.000

10.204(2.032–52.631)

0.005

 No

103

76.3

20

14.81

135

51.53

1

 

1

 

Treatment

          

 Standard treatment

136

57.87

53

22.55

235

89.69

2.566(0.966–6.816)

0.059

0.447(0.027–7.449)

0.575

 Individualized treatment

9

33.33

9

33.33

27

10.31

1

 

1

 

Hosipitalization

         

 No

115

58.67

41

20.92

196

74.81

0.509(0.263–0.987)

0.046

0.365(0.066–2.009)

0.247

 Yes

30

45.45

21

31.82

66

25.19

1

 

1

 

Liver protection drugs

         

 Yes

38

48.72

24

30.77

78

29.77

1.779(0.946–3.344)

0.074

1.764(0.935–142.857)

0.056

 NO

107

58.15

38

20.65

184

70.23

1

 

1

 

First-line oral anti-TB agents

         

Ethambutol

          

 R

58

54.21

25

23.36

107

40.84

0.987(0.538–1.81)

0.965

1.721(0.37–8.009)

0.489

 S

87

56.13

37

23.87

155

59.16

1

 

1

 

Injectable anti-TB agents

         

Streptomycin

          

 R

92

57.5

34

21.25

160

61.07

1.43(0.782–2.614)

0.246

1.85(0.46–7.451)

0.387

 S

53

51.96

28

27.45

102

38.93

1

 

1

 

Kanamycin

          

 R

7

36.84

9

47.37

19

7.25

0.299(0.106–0.843)

0.022

0.137(0.005–3.663)

0.236

 S

138

56.79

53

21.81

243

92.75

1

 

1

 

Fluoroquinolones

         

Ofloxacin

          

 R

14

35.9

14

35.9

39

14.89

0.366(0.163–0.825)

0.015

0.793(0.101–6.209)

0.825

 S

131

58.74

48

21.52

223

85.11

1

 

1

 

Treatment regularity

         

 No

2

7.14

18

64.29

28

10.69

29.411(6.535–125)

0.000

47.619(5.025–500)

0.001

 Yes

143

61.11

44

18.8

234

89.31

1

 

1

 

Resistant patterne

         

 R/H

38

52.05

21

28.77

73

27.86

0.693(0.364–1.319)

   

 R/H/E

13

61.90

4

19.05

21

8.02

1.428(0.447–4.566)

   

 R/H/S

42

66.67

11

17.46

63

24.05

1.891(0.899–3.978)

   

 R/H/S/E

37

56.92

12

18.46

65

24.81

1.427(0.686–2.969)

   

 R/H/Ofx/Km/S/E

3

30.00

6

60.00

10

3.82

0.131(0.026–0.666)

0.014

  
  1. aothers including student and other occupation not investigated in specific
  2. bpermanent local residence classified into “residence”, otherwise “Floating”
  3. cTreatment success including cured(Cure)and treatment completed(TC)
  4. dOR adjusted odd ratio, CI confidence interval
  5. eH isoniazid, R rifampicin, E ethambutol, S streptomycin, Km kanamycin, Ofx ofloxacin. Analysis was done for patterns with at least 10 cases in total