Determination of parasitic burden in the brain tissue of infected mice in acute toxoplasmosis after treatment by fluconazole combined with sulfadiazine and pyrimethamine

Table 3 The parasite burden in different group of treatment by various doses of FLZ + PYR

Groups	Day after challenge		P value
Groups	Day after the end of medication	Last day (before death)	P value
Untreated	–	11,804,800	P < 0.001
PYR	1,870,800	916,000	P < 0.001
P value	P < 0.009
Untreated	-	11,804,800	P < 0.001
FLU 20 mg + PYR	1,746,000	1,052,000	P < 0.001
P value	P < 0.009
Untreated	–	11,804,800	P < 0.001
FLU 40 mg + PYR	1,592,400	1,556,000	P < 0.001
P value	P < 0.009
Untreated	–	11,804,800	P < 0.001
FLU 80 mg + PYR	2,466,000	2,004,400	P < 0.001
P value	P < 0.009

Results are the mean ± standard deviation of the quantity of DNA obtained from three different treatment groups. Kruskal–Wallis test compared the groups at the significance level of 0.05. Mann–Whitney U test was used for multiple comparisons between groups and different days. Bonferroni correction was used to change the significance level to 0.01 and 0.025. Parasite load of Toxoplasma tachyzoites indicated the statistically significant difference among t the two groups and different days

ISSN: 2047-783X