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Table 1 Clinicopathological characteristics of patients with paraproteinemia and renal damage

From: Clinicopathological characteristics of patients with paraproteinemia and renal damage

  MGRS (n  =  42) MM (n  =  14) MGUS (n  =  19) Renal monoIg (n  =  21) P value
Male [n (%)] 25 (59.5) 9 (64.3) 12 (63.2) 8 (38.1) 0.292
Age (year) 57.0  ±  10.6 57.0  ±  7.0 53.2  ±  11.5 43.3  ±  15.9c,e,f 0.000
Renal disease duration before renal biopsy (months) 11.0  ±  11.1 6.3  ±  8.1 21.1  ±  44.1 26.8  ±  57.5 0.210
Hematuria [n (%)] 12 (27.9) 2 (15.4)d 10 (52.6) 12 (57.1)c,e 0.021
Proteinuria (g/24 h) 3.9  ±  2.7 3.3  ±  2.6 2.8  ±  2.6 1.8  ±  2.3c 0.026
Albumin (g/L) 27.7  ±  7.0a,b,c 36.6  ±  6.8 32.7  ±  7.4 35.3  ±  7.1 0.000
Hemoglobin (g/L) 113.6  ±  21.3 99.9  ±  16.7a,d,e 131.2  ±  16.3b 122.9  ±  19.6 0.000
SCr (μmol/L) 160.2  ±  205.8 359.1  ±  385.4a,d,e 102.6  ±  103.5 104.1  ±  60.2 0.002
eGFR (mL/min/1.73m2) 68.9  ±  39.7 45.3  ±  43.6a,d,e 77.7  ±  25.4 75.3  ±  34.9 0.054
Low serum C3 [n (%)] 15 (35.7) 3 (21.4) 1 (5.3)b,f 7 (33.3) 0.078
Abnornal serum κ/λ ratio [n (%)] 19 (45.2) 11 (78.6)a,d 8 (42.1) 0 (0)c,e,f 0.000
Abnormal urine κ/λ ratio [n (%)] 17 (42.5) 13 (92.9)a,d 5 (29.4) 0 (0)c,e,f 0.000
Abnormal sIFE [n (%)] 25 (61.0)a,b 13 (92.9) 19 (100) 0 (0)c,e,f 0.000
Abnormal uIFE [n (%)] 23 (76.7) 12 (85.7) 8 (53.3) 0 (0)c,e,f 0.002
κ sIFE, [n (%)] 9 (37.5) 7 (53.8) 11 (57.9) 0 (0) 0.371
κ uIFE, [n (%)] 5 (22.7) 6 (50.0) 4 (50.0) 0 (0) 0.183
Renal monotypic κ [n (%)] 16 (40.0) 7 (53.8) 0 (0)b,d 0 (0)c,e,f 0.000
Global glomerulosclerosis (%) 16.7  ±  18.0 17.9  ±  24.3 13.3  ±  10.1 15.1  ±  16.0 0.863
Segmental glomerulosclerosis (%) 0.8  ±  3.7 1.1  ±  1.9 1.2  ±  3.0 1.5  ±  2.9 0.223
Crescents (%) 4.1  ±  14.4 2.2  ±  3.8e 4.1  ±  7.6 13.3  ±  2.9 0.024
IFTA 1.29  ±  0.84 2.0  ±  1.18a,d 1.05  ±  0.71 1.29  ±  0.90 0.029
Interstitial inflammation 1.20  ±  0.90 2.00  ±  1.17a,d 1.11  ±  0.81 1.52  ±  1.03 0.000
  1. MGRS monoclonal gammopathy of renal significance; MM multiple myeloma; MGUS monoclonal gammopathy of undetermined significance; MIg monoclonal immunoglobulin; monoIg monotypic immunoglobulin; SCr serum creatinine; eGFR the estimated glomerular filtration rate; sIFE serum immunofixation electrophoresis; uIFE urine immunofixation electrophoresis; IFTA interstitial fibrosis/tubular atrophy
  2. aP  <  0.05, MGRS vs MM group
  3. bP  <  0.05, MGRS vs MGUS group
  4. cP  <  0.05, MGRS vs renal monoIg group
  5. dP  <  0.05, MM vs MGUS group
  6. eP  <  0.05, MM vs renal monoIg group
  7. fP  <  0.05, MGUS vs renal monoIg group