Fig. 7

Association of AB0 blood group heterozygosity with development of WHO° 2b and WHO° 3 disease. A logistic regression analysis included as covariates gender, age, multispreading (whether infection event affected at least 3 individuals), ‘‘protective “ HLA alleles (as defined on the Results section), the further class I HLA alleles C2 and HLA-Bw4 (included on this analysis for their binding to distinct killer-cell immunoglobulin-like receptors (KIRs) expressed by natural killer-cells), the heterozygous CCR5 delta 32 mutation and AB0 blood group allele heterozygosity. Odds ratios and their confidence intervals for individuals with COVID 19 WHO° 1 to WHO° 3 are shown