Fig. 8

HLA alleles as most informative prognostic biomarkers of disease duration. A Cox regression analysis included as covariates gender, age, number of ‘‘protective “ HLA alleles, HLA encoded NK-KIR ligand for KIR2DL1/ KIR2DS1 (HLA-C2) and KIR3DL1/KIR3DS1 (HLA-Bw4), heterozygous CCR5 delta 32 mutation, as well as AB0 blood group allele homozygosity. A The results of a Cox regression analysis performed in 81 individuals for whom all the listed information is available. B shows the results of a Cox regression analysis performed in 51 individuals with WHO° 1 and WHO° 2a disease. C The results of a Cox regression analysis performed in 30 individuals with WHO° 2a and WHO° 3 disease. Hazard ratio for disease duration and respective 95% confidence interval is shown for the first step and the last step after backward conditional regression