NR4A3 and CCL20 clusters dominate the genetic networks in CD146+ blood cells during acute myocardial infarction in humans

Table 1 Category of DCGs

Genes	Name	Clustering coefficient fold-change	Gene expression fold-change
CC^highGeExp^high
NR4A3	Nuclear receptor subfamily 4 group A member 3	15.7	0.422
CCL20	C–C motif chemokine ligand 20	10.2	0.379
CC^highGeExp^low
SOCS3	Suppressor of cytokine signaling 3	5.35	0.085
PLIN2	Perilipin 2	4.56	0.128
FOSL2	FOS like 2, AP-1 transcription factor subunit	3.30	0.163
CC^lowGeExp^high
ANXA3	Annexin A3	1.58	0.482
AC079305.10	Unnamed	1.40	0.417
NLRP3	NLR family pyrin domain containing 3	0.982	0.411
IL1R2	Interleukin 1 receptor type 2	0.523	0.421
MMP9	Matrix metallopeptidase 9	0.749	0.377
NR4A2	Nuclear receptor subfamily 4 group A member 2	0.767	0.375
PYGL	Glycogen phosphorylase L	0.498	0.372
LILRB2	Leukocyte immunoglobulin like receptor B2	0.432	0.349
FCER1G	Fc fragment of IgE receptor Ig	0.633	0.339
CXCL16	C–X–C motif chemokine ligand 16	0.263	0.324
CLEC4E	C-type lectin domain family 4 member E	0.153	0.327
CC^lowGeExp^low
ITPRIP	Inositol 1,4,5-trisphosphate receptor interacting protein	2.03	0.158
SYTL3	Synaptotagmin like 3	1.98	0.209
MAP3K8	Mitogen-activated protein kinase kinase kinase 8	1.34	0.169
CDKN1A	Cyclin dependent kinase inhibitor 1A	1.41	0.246
SKIL	SKI like proto-oncogene	1.05	0.284
TMCC3	Transmembrane and coiled-coil domain family 3	1.13	0.295
BCL6	BCL6 transcription repressor	0.818	0.239
PELI1	Pellino E3 ubiquitin protein ligase 1	0.489	0.109
GABARAPL1	GABA type A receptor associated protein like 1	0.353	0.182
RNF144B	Ring finger protein 144B	0.524	0.263
GLUL	Glutamate-ammonia ligase	0.198	0.165

DCGs differential connectivity genes; CC clustering coefficient; GeExp gene expression

ISSN: 2047-783X