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Table 2 Laboratory parameters and biomarkers at ICU day 0 after adjusting of covariates

From: Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry

Variables Steroids IL6-RAs Both P SMD
Na 804.07 572.13 693.34   
Blood glucose (highest) 10.47 (5.54) 9.88 (5.13) 10.87 (5.55) 0.55 0.122
FiO2% (0.21 to 1.0) (lowest) 0.56 (0.25) 0.52 (0.24) 0.57 (0.24) 0.34 0.145
FiO2% (0.21 to 1.0) (highest) 0.79 (0.25) 0.72 (0.26) 0.84 (0.22) 0.01 0.33
FiO2 (0.21 to 1.0) at the time of blood gas 0.76 (0.56) 0.62 (0.28) 0.73 (0.26) 0.02 0.259
Arterial PaO2 at time of FiO2 88.94 (51.19) 84.16 (30.70) 91.54 (47.87) 0.56 0.116
Alanine aminotransferase (ALT/SGPT) (highest) 0.82 (0.76) 0.96 (1.25) 0.92 (1.14) 0.66 0.086
Aspartate aminotransferase (AST/ SGOT) (highest) 1.18 (1.25) 1.29 (1.34) 1.34 (1.74) 0.71 0.074
Alkaline phosphatase (highest) 1.49 (0.90) 1.44 (0.77) 1.69 (1.06) 0.43 0.177
Total bilirubin (highest) 13.85 (11.45) 10.81 (8.43) 13.04 (11.99) 0.033 0.195
C-reactive protein (CRP) (highest) 144.59 (111.78) 122.95 (108.34) 142.54 (100.90) 0.38 0.134
Ferritin (highest) 1264.92 (1272.46) 1918.15 (4028.79) 1379.02 (1710.94) 0.40 0.156
Lactate dehydrogenase (LDH) (highest) 12.66 (8.84) 9.65 (5.03) 9.46 (5.32) 0.001 0.298
Leukocyte count (lowest) 10.69 (6.39) 8.56 (5.52) 10.10 (4.54) 0.02 0.256
Leukocyte count (highest) 11.13 (6.65) 9.22 (5.28) 10.78 (5.79) 0.01 0.219
Lymphocyte count (lowest) 15.79 (19.99) 13.32 (10.84) 13.89 (12.14) 0.28 0.106
d-Dimer 1746.03 (2726.93) 1193.26 (2758.81) 1064.68 (3171.54) 0.20 0.158
Procalcitonin (highest) 2.20 (5.19) 0.88 (1.98) 1.11 (3.17) 0.02 0.225
Fibrinogen level (highest) 6.19 (2.09) 6.17 (1.56) 6.40 (2.01) 0.88 0.078
Interleukin 6 (IL-6) (highest) 123.27 (162.97) 202.84 (196.81) 283.06 (228.51) 0.31 0.541
Highest lactate 2.44 (2.05) 1.86 (0.78) 2.22 (1.34) 0.005 0.273
  1. Data presented as mean (SD). Units presented as SI units for the following: PaO2 in mmHg; ALT/SGPT, AST/SGOT, alkaline phosphatase, and lactate dehydrogenase (µkat/L); bilirubin (µmol/L); ferritin (mcg/L); leukocytes (×109/L); d-dimer mg/L; procalcitonin (mcg/L); fibrinogen (g/L); interleukin 6 (il-6) (pg/mL); lactate (mmol/L); platelet (×109/L)
  2. The following presented as conventional unit: lymphocyte (% of white blood cells); C-reactive protein (mg/L)
  3. FiO2: fractional inspired oxygen; IL6-RAs: interleukin-6 receptor antagonists; PaO2: arterial oxygen partial pressure
  4. aThe total number is slightly different in the post-IPW pseudo-dataset as a result of the weighting
  5. Bold values indicate a significant value at 5% level of significance