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Table 2 Laboratory parameters and biomarkers at ICU day 0 after adjusting of covariates

From: Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry

Variables

Steroids

IL6-RAs

Both

P

SMD

Na

804.07

572.13

693.34

  

Blood glucose (highest)

10.47 (5.54)

9.88 (5.13)

10.87 (5.55)

0.55

0.122

FiO2% (0.21 to 1.0) (lowest)

0.56 (0.25)

0.52 (0.24)

0.57 (0.24)

0.34

0.145

FiO2% (0.21 to 1.0) (highest)

0.79 (0.25)

0.72 (0.26)

0.84 (0.22)

0.01

0.33

FiO2 (0.21 to 1.0) at the time of blood gas

0.76 (0.56)

0.62 (0.28)

0.73 (0.26)

0.02

0.259

Arterial PaO2 at time of FiO2

88.94 (51.19)

84.16 (30.70)

91.54 (47.87)

0.56

0.116

Alanine aminotransferase (ALT/SGPT) (highest)

0.82 (0.76)

0.96 (1.25)

0.92 (1.14)

0.66

0.086

Aspartate aminotransferase (AST/ SGOT) (highest)

1.18 (1.25)

1.29 (1.34)

1.34 (1.74)

0.71

0.074

Alkaline phosphatase (highest)

1.49 (0.90)

1.44 (0.77)

1.69 (1.06)

0.43

0.177

Total bilirubin (highest)

13.85 (11.45)

10.81 (8.43)

13.04 (11.99)

0.033

0.195

C-reactive protein (CRP) (highest)

144.59 (111.78)

122.95 (108.34)

142.54 (100.90)

0.38

0.134

Ferritin (highest)

1264.92 (1272.46)

1918.15 (4028.79)

1379.02 (1710.94)

0.40

0.156

Lactate dehydrogenase (LDH) (highest)

12.66 (8.84)

9.65 (5.03)

9.46 (5.32)

0.001

0.298

Leukocyte count (lowest)

10.69 (6.39)

8.56 (5.52)

10.10 (4.54)

0.02

0.256

Leukocyte count (highest)

11.13 (6.65)

9.22 (5.28)

10.78 (5.79)

0.01

0.219

Lymphocyte count (lowest)

15.79 (19.99)

13.32 (10.84)

13.89 (12.14)

0.28

0.106

d-Dimer

1746.03 (2726.93)

1193.26 (2758.81)

1064.68 (3171.54)

0.20

0.158

Procalcitonin (highest)

2.20 (5.19)

0.88 (1.98)

1.11 (3.17)

0.02

0.225

Fibrinogen level (highest)

6.19 (2.09)

6.17 (1.56)

6.40 (2.01)

0.88

0.078

Interleukin 6 (IL-6) (highest)

123.27 (162.97)

202.84 (196.81)

283.06 (228.51)

0.31

0.541

Highest lactate

2.44 (2.05)

1.86 (0.78)

2.22 (1.34)

0.005

0.273

  1. Data presented as mean (SD). Units presented as SI units for the following: PaO2 in mmHg; ALT/SGPT, AST/SGOT, alkaline phosphatase, and lactate dehydrogenase (µkat/L); bilirubin (µmol/L); ferritin (mcg/L); leukocytes (×109/L); d-dimer mg/L; procalcitonin (mcg/L); fibrinogen (g/L); interleukin 6 (il-6) (pg/mL); lactate (mmol/L); platelet (×109/L)
  2. The following presented as conventional unit: lymphocyte (% of white blood cells); C-reactive protein (mg/L)
  3. FiO2: fractional inspired oxygen; IL6-RAs: interleukin-6 receptor antagonists; PaO2: arterial oxygen partial pressure
  4. aThe total number is slightly different in the post-IPW pseudo-dataset as a result of the weighting
  5. Bold values indicate a significant value at 5% level of significance
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European Journal of Medical Research

ISSN: 2047-783X

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