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Table 2 Adverse reactions of pirfenidone treatment

From: The effects and safety of pirfenidone in the treatment of idiopathic pulmonary fibrosis: a meta-analysis and systematic review

Study ID Main adverse reactions Major adverse reactions leading to interruption of treatment
Azuma 2005 Photosensitivity (43.8%), gastrointestinal discomfort (30.1%), anorexia (31.5%) Photosensitivity (5 cases), vomiting, fever, abnormal liver function, dizziness, facial paralysis, hepatocellular tumor (1 case each)
CAPACITY 2011 Nausea (36.0%), skin rash (32.0%) Nausea (36.0%), rash (28.1%), headache (25.9%), cough (25.2%), diarrhea (22.3%)
Huang 2015 Skin rash (39.5%), nausea (5.26%), diarrhea (7.89%) NA
King 2014 Nausea (36.0%), rash (28.1%), headache (25.9%), cough (25.2%), diarrhea (22.3%) Acute exacerbation of IPF, elevated liver enzymes, pneumonia (both 1.1%)
Lei 2018 Photosensitivity, loss of appetite, fatigue NA
Li 2015 NA NA
Li 2016 Gastrointestinal reaction, abnormal liver function NA
Taniguchi 2010 Photosensitivity (51.4%), nasopharyngitis (49.5%), anorexia (16.5%) Photosensitivity (2.8%), lung cancer (1.8%), fever (1.8%), respiratory failure (1.8%)