Table 1 Cefazolin-induced anemia
From: Cefazolin-induced hemolytic anemia: a case report and systematic review of literature
Author (Year) | Study design | Presentation | Hemo-globin nadir | Penicillin sensitivity (Y/N) | DAT result ( ±) | Other anemia causes excluded (Y/N) | Outcome |
|---|---|---|---|---|---|---|---|
Moake et al. [2] | Case report | 39 yo F with right renal artery stenosis underwent a renal artery bypass with pre-operative and 4-day postoperative use of cefazolin | 6.3 | Y | + | Y | Complete resolution |
Imam et al. [3] | Case report | 70 yo M with acute anemia and elevated LDH post cefazolin administration; underwent mitral and tricuspid valve repair and Maze procedure | Δ3.0 g | NS | – | N ceftriaxone induced hemolytic anemia was also implicated | Complete resolution |
Cerynik et al. [4] | Case report | 50 yo M right total knee arthroplasty given pre-operative cefazolin developed anemia, then recovered; administration cefazolin 10 week postop due to knee swelling induced anemia again | 14.9 6.9 Δ8 | N | + | Y | Complete resolution |
Macy, E. and Contreras, R. [5] | Retrospective population based analysis | 37 yo F cardiac catheterization given pre-operative cefazolin with elevated lactate dehydrogenase post cefazolin administration | 7.6 | NS | NS | NS | Complete resolution |
Moghaddam et al. [6] | Case report | 24 yo F hysteroscopy for resection of the uterine septum | 12.5 7.0 Δ5.5 | N | + | N | The patient died of multiple organ failure |