Table 2 The function of 10 hub genes

IFIH1

Encoding MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response, involves in a proinflammatory response that includes interferons and plays an important role in enhancing natural killer cell function in malaria infection

DDX58

Involving in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response

ISG15

Including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections

EGR1

Encoding a nuclear protein which functions as a transcriptional regulator

OASL

Diseases associated with OASL include West Nile Fever and West Nile Virus Infection

SAMD9

Encoding a sterile alpha motif domain-containing protein that may play a role in regulating cell proliferation and apoptosis

SAMD9L

Encoding a cytoplasmic protein that acts as a tumor suppressor but also plays a key role in cell proliferation and the innate immune response to viral infection

XAF1

Encoding a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. (IAP proteins bind to and inhibit caspases which are activated during apoptosis)

IFITM1

Involving Interferon gamma signaling and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

TNFSF10

Encoding a cytokine that preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells