Fig. 1
From: Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency
Hypothetical model for the development of NADRI. ? means a point of divergence. NADRI normoalbuminuric diabetes with renal insufficiency, eGFR estimated glomerular filtration rate, IRS insulin resistance syndrome, IFTA interstitial fibrosis and tubular atrophy, UC underlying conditions, PKC-β protein kinase C-β, AT 1R angiotensin type 1 receptor, RAAS renin-angiotensin-aldosterone system, 8-OHdG 8-hydroxydeoxyguanosine, NL nephron loss, EI endothelial injury