Variable | 12-h before-ECMO initiation (n = 83) | 2-h before-ECMO initiation (n = 78) | 72-h after-ECMO initiation (n = 71) | 12-h before-ECMO removal (n = 67) | 2-h before-ECMO removal (n = 62) | p- value |
---|---|---|---|---|---|---|
Ventilatory settings | ||||||
 Peak pressure, cmH2O | 34.2 ± 7.2 (15–45) | 35.4 ± 5.8 (19–45) | 30 ± 6 (10–50) | 29.7 ± 7.4 (5–51) | 32.1 ± 5.8 (15–50) | 0.010* |
 Plateau pressure, cmH2O | 30.1 ± 5.1 (17–38) | 30.4 ± 5.8 (17–41) | 26.6 ± 4.7 (10–38) | 26.5 ± 5.8 (15–41) | 27.7 ± 6.8 (15–50) | 0.214 |
 PEEP, cmH2O | 12.5 ± 2.9 (5–18) | 13.1 ± 2.6 (5–19) | 10.1 ± 3 (5–17) | 9.2 ± 2.8 (2–16) | 9.6 ± 3 (5–22) | 0.588 |
 FiO2, % | 95.3 ± 10.8 (55–100) | 95.2 ± 12.2 (50–100) | 54.8 ± 19.8 (30–110) | 62.6 ± 25.5 (30–100) | 66.9 ± 28.2 (30–100) | 0.817 |
 Tidal volume, ml | 400.9 ± 50.6 (280–500) | 377 ± 74.3 (45–491) | 266.2 ± 106.3 (30–531) | 275 ± 142.7 (20–595) | 290.8 ± 161.1 (2.8–625) | 0.708 |
ABG analyses | ||||||
 pH in ABG | 7.2 ± 0.13 (7–7.45) | 7.3 ± 0.12 (6.95–7.48) | 7.32 ± 0.13 (6.9–7.6) | 7.32 ± 0.9 (7.1–7.5) | 7.3 ± 0.15 (6.8–7.53) | 0.514 |
 PaO2 in ABG, mmHg | 62.9 ± 15.7 (38.2–107) | 61.1 ± 17.7 (39–124) | 74 ± 29.2 (34–179) | 71 ± 27.1 (36–177) | 70 ± 26.3 (29–169) | 0.002* |
 PCO2 in ABG, mmHg | 61.8 ± 20.3 (33.7–126) | 66.8 ± 29 (29.3–150) | 49.3 ± 13.1 (23.4–98) | 50.3 ± 14.3 (22.4–106) | 51 ± 15 (20.5–96) | 0.042* |
 HCO3 in ABG, mEq/L | 24.4 ± 5.9 (12.4–39) | 24.8 ± 5.9 (14.9–40) | 24.5 ± 6.3 (5.6–37.3) | 23.8 ± 6.4 (5.4–34.8) | 23 ± 6.6 (5.2–35.1) | 0.598 |
 Lactate in ABG, mmol/l | 2.9 ± 2.5 (0.9–10.7) | 3.9 ± 6.7 (0.8–37.1) | 3.7 ± 5 (0.7–21) | 3.8 ± 4.9 (0.6–18) | 5.4 ± 6.6 (0.5–30) | 0.398 |
Vital signs | ||||||
 Mean arterial pressure, mmHg | 81.4 ± 13.7 (60–116) | 78.7 ± 14.4 (54–124) | 76.1 ± 15.9 (43–133) | 77.7 ± 19.9 (45–181) | 71.5 ± 21.2 (33–145) | 0.322 |
 Heart rate, beats per minute | 104.5 ± 20.7 (54–148) | 104 ± 22.6 (50–165) | 103.1 ± 22.4 (53–158) | 97.8 ± 22.3 (56–145) | 91.1 ± 25.8 (34–133) | 0.251 |
 Central venous pressure, mmHg | 13.4 ± 4.5 (7–22) | 22.1 ± 31.5 (7–111) | 20.8 ± 13.4 (8.3–88) | 13.1 ± 2.8 (9–21) | 17.4 ± 21.5 (6–97) | 0.293 |