Fig. 1

Histological evidence of HHV-8-related Kaposi sarcoma on patient’s skin, oral mucosa, and cervical lymph node. Courtesy of Prof. Fabio Facchetti, University Anatomic Pathology Division, Spedali Civili Hospital, Brescia (Italy). On the left, low power view of skin (A), oral mucosa (B), and cervical lymph node (C) biopsies, involved by Kaposi sarcoma. Images in the middle show abnormal vessels and spindle cell proliferation, with intermingled erythrocytes and figures on the right show the intense positivity of tumor cells for HHV-8 LANA-1 antigen (Left and middle figures: hematoxylin–eosin stain; right figures: immunohistochemistry using monoclonal antibody anti-LANA-1 HHV8-associated antigen, developed with diaminobenzidine and counterstained with Meyer’s hematoxylin)