Table 2 Significantly associated AhR/Wnt-markers within never and ever smokers
From: Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer
SNP | Cyto band | MAF (%) | Gene | Model 2 | Model 1 | Model 3 | ||
|---|---|---|---|---|---|---|---|---|
p value | OR | 95% CI | OR | OR | ||||
Never smoker | ||||||||
Imputed | ||||||||
rs202198518a | 7p21.1 | 14 | AHR | 3.4 × 10–13 | 0.72 | 0.66–0.79 | 0.71 | 0.90 ns |
Imputed | ||||||||
rs2237297a | 14 | 9.9 × 10–14 | 0.71 | 0.65–0.78 | 0.71 | 0.90 ns | ||
Imputed | ||||||||
rs1133683 | 17q24.1 | 42 | Axin2 | 1.0 × 10–12 | 1.27 | 1.19–1.35 | 1.27 | 0.95 ns |
Imputed | ||||||||
rs2240307 | 5 | 7.7 × 10–24 | 0.41 | 0.34–0.49 | 0.40 | 0.62 ns | ||
Imputed | ||||||||
rs35285779a | 9 | 3.2 × 10–22 | 0.58 | 0.52–0.65 | 0.58 | 1.10 ns | ||
Imputed | ||||||||
rs35415678a | 9 | 3.7 × 10–19 | 0.62 | 0.56–0.69 | 0.62 | 1.10 ns | ||
Imputed | ||||||||
rs288326 | 2q32.1 | 10 | FRZB | 2.5 × 10–8 | 1.42 | 1.25–1.60 | 1.41 | 0.98 ns |
Imputed | ||||||||
rs17037102 | 4q25 | 15 | DKK2 | 7.4 × 10–15 | 0.69 | 0.63–0.76 | 0.69 | 1.09 ns |
Ever smoker | ||||||||
Genotyped | ||||||||
rs12532321 | 7p14.1 | 45 | SFRP4 | 1.3 × 10–9 | 1.14 | 1.09–1.19 | 1.15 | 1.13ss |
Genotyped | ||||||||
rs7811872 | 36 | 1.3 × 10–8 | 0.88 | 0.84–0.92 | 0.88 | 0.88gws | ||
Genotyped | ||||||||
rs10226308 | 42 | 1.8 × 10–8 | 0.88 | 0.85–0.92 | 0.89 | 0.89gws | ||
Genotyped | ||||||||
rs10488617 | 42 | 1.6 × 10–8 | 0.88 | 0.85–0.92 | 0.89 | 0.89gws | ||
Genotyped | ||||||||
rs2722278 | 16 | 5.6 × 10–10 | 1.20 | 1.13–1.27 | 1.16 | 1.20gws | ||
Genotyped | ||||||||
rs2722279 | 11 | 9.0 × 10–9 | 1.22 | 1.14–1.31 | 1.17 | 1.23gws | ||
Genotyped | ||||||||
rs7811420 | 43 | 7.9 × 10–8 | 0.89 | 0.85–0.93 | 0.89 | 0.89gws | ||
Imputed | ||||||||
rs2073664 | 8p11.21 | 9 | DKK4 | 9.4 × 10–11 | 1.20 | 1.14–1.27 | 1.15 | 1.08ss |