Skip to main content
Fig. 5 | European Journal of Medical Research

Fig. 5

From: Flurbiprofen inhibits cell proliferation in thyroid cancer through interrupting HIP1R-induced endocytosis of PTEN

Fig. 5

Flurbiprofen inhibits proliferation of thyroid cancer cells and affects HIP1R-mediated endocytosis of PTEN. SW579 and TPC-1 cells were treated with 10 nM flurbiprofen or DMSO. A Cell viability at 12, 24, 36, 48 and 60 h in SW579 and TPC-1 cells examined by CCK-8 assay. B After treatment with flurbiprofen for 48 h, the interaction between HIP1R and PTEN in SW579 cells examined by co-IP. C After treatment with flurbiprofen for 48 h, protein levels of membrane-binding PTEN and intracellular PTEN in SW579 cells. GAPDH was the internal control. D and E SW579 cells were transfected with siCtrl, siHIP1R or siPTEN and also treated with 10 nM flurbiprofen or DMSO. Cell viability at 12, 24, 36, 48 and 60 h in SW579 cells examined by CCK-8 assay

Back to article page