Case | Study | Years/gender | Primary disease | Conditioning regimen | Transplant | Time | Suspected cause | Symptom | Creatine kinase | AKI | Therapy | Fate |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Volin, et al., 199011 | 27/M | CML | Cyclophosphamide, TBI | MSDT |  + 3 month | CsA, corticosteroids, fluconazole | Grand mal seizure, bilateral lower extremity weakness, pain, dark red urine | 81,000 U/L | Yes | Peritoneal dialysis | Died |
2 | Maruyama, et al.,199412 | 17/F | Ki-1 lymphoma | Melphalan, etoposide and TBI | PBSCT |  + 23 day | CMV infection | Severe muscle weakness, muscle pain | 110 mU/mL (< 25 mU/mL) | Yes (Cr = 4.2 mg/dl) | Hydration, alkalization | Survive |
3 | Hoshi, et al.,199913 | 38/M | CC | Ifosfamide, carboplatin, etoposide | Auto-HSCT | 0Â day | HDC, pretreatment renal dysfunction, ifosfamide, sedatives | Dyspnea, hemoptysis, dark red urine | 6150Â IU/L | Yes | Hemodialysis | Died (respiratory failure) |
4 | Pugliese, et al.,200014 | Unknown | Breast cancer | Cyclophosphamide | Auto-HSCT |  + 7 day | Vancomycin | Severe muscle weakness | 1756 U/L | No | Hydration, alkalization | Survive |
5 | Rossi, et al.,200015 | 16/M | ATL | TBI, etoposide, cyclophosphamide | MSDT |  + 11 day | ABCD | Muscular hypertonus, trismus, severe muscular pain | 21,730 U/L | No | Intensive care unit | Survive |
6 | Shima, et al.,200216 | 47/F | ATLL | TBI, cyclophosphamide | NO | Pre-transplant period | High-dose cyclophosphamide | Generalized convulsions, muscle fatigue, severe acidosis | 34,863Â IU/L | No | Hydration, alkalization | Survive |
7 | Tong, et al.,200517 | 66/M | MM | TBI, cyclophosphamide | Auto-HSCT, MSDT |  + 22 day | CsA, simvastatin | Bilateral lower extremity weakness, pain | 29,253 U/L | Yes (Cr = 2 mg/dl) | Hydration, alkalization | Survive |
8 | Vives, et al.,200818 | 54/M | AML | Fludarabine, busulfan | MSDT |  + 1 month | Simvastatin, CsA, risperidone | Pelvic muscle weakness, severe muscular pain | 88 370 U/L | Yes (Cr = 4.81 mg/dl) | Hydration, alkalization | Survive |
9 | Jiang, et al.,201619 | 41/F | CML | Busulfan, cyclophosphamide | MSDT |  + 55 day | Infection, GVHD, metabolic disorders, CsA, methylprednisolone | Anasarca and muscle tenderness | 1614 μg/L(25–200 μg/L) | Yes | Unknown | Died |
10 | Sokolova, et al.,201720 | 21/M | GCT | Unknown | Auto-HSCT |  + 12 day | Paclitaxel, ifosfamide, carboplatin, etoposide | Bilateral leg pain | 30,841 IU/L | No | Hydration, alkalization | Survive |
11 | Our case | 55/M | HAAA | Fludarabine, ATG, cyclophosphamide | Haplo-HSCT |  + 7 day | Gene mutation, muscle strain, Infection, TMP/SMX, atorvastatin | Muscle pain, dark urine, swelling of the left thigh | 852 U/L | Yes | Hydration, alkalization | Died |