Peak value of serum KL-6 may be useful for predicting poor prognosis of severe COVID-19 patients

Table 2 Laboratory findings of COVID-19 patients in the good and poor prognosis groups

	Total N = 147	Good prognosis N = 108	Poor prognosis N = 39	p value
Initial value
KL-6, U/mL	356 [238–539]	317 [227–473]	477 [304–712]	< 0.001
LDH, U/L	359 [293–495]	349 [267–465]	453 [318–583]	0.009
D-dimer, ng/mL	1.5 [0.7–3.3]	1.3 [0.5–3.0]	2.7 [1.4–5.5]	0.004
Ferritin, ng/mL	666 [424–1283]	707 [425–1219]	610 [422–1589]	0.82
PCT, ng/mL	0.18 [0.09–0.41]	0.16 [0.08–0.38]	0.22 [0.13–0.58]	0.13
CRP, mg/dL	8.4 [4.7–15.6]	9.2 [5.1–15.5]	6.8 [2.9–17.5]	0.20
WBC, /μL	7700 [5200–10700]	7700 [5300–10400]	7700 [4300–12200]	0.69
Lymphocyte, /μL	683 [375–964]	673 [380–948]	684 [362–998]	0.98
Peak value
KL-6, U/mL	709 [406–1165]	497 [355–826]	1472 [1137–2139]	< 0.001
LDH, U/L	493 [345–668]	415 [328–533]	755 [628–1155]	< 0.001
D-dimer, ng/mL	9.8 [3.8–30.6]	6.8 [2.8–20.2]	30.7 [11.5–44.3]	< 0.001
Ferritin, ng/mL	911 [536–1580]	862 [475–1428]	1147 [635–2104]	0.021

Good prognosis group included patients requiring supplemental oxygen or invasive mechanical ventilation within 28 days. Poor prognosis group included patients requiring invasive ventilation over 28 days or who were discharged to death
Initial value was defined the first value obtained within the 3rd day of hospitalization; peak value was defined the peak value during the entire hospitalization
Data are expressed as median (1st IQR-3rd IQR). p Values were calculated with the Mann–Whitney U test
KL-6 Krebs von den Lungen 6, LDH lactate dehydrogenase, PCT procalcitonin, CRP C-reactive protein, WBC white blood cell count

ISSN: 2047-783X