Fig. 3

C-176 mitigates pulmonary apoptosis and pyroptosis in mice exposed to IR. A Representative photomicrographs of GSDMD-positive cells; C TUNEL-positive cells in the lung; B the number of GSDMD-positive cells; and D the percentage of TUNEL-positive cells in the lung caused by the indicated stimuli 3 h after IR. Scale bar = 50 μm. Arrows indicate GSDMD- and TUNEL-positive cells. Data are presented as the mean ± SD (n = 6). Sham, IR, C-176, and vehicle are described above. ****P < 0.0001, ***P < 0.001, **P < 0.01