Fig. 4

C-176 mitigates pulmonary pyroptosis- and apoptosis-associated factors in mice exposed to IR. A Representative Western blot of cleaved caspase-1 (a marker for pyroptosis) and cleaved caspase-3 (a marker for apoptosis) in the lung caused by the indicated stimuli; B the ratio between the optical density value of cleaved caspase-1 and GAPDH in the lung, as evaluated by Western blot; C the ratio between the optical density value of cleaved caspase-3 and GAPDH in the lung, as evaluated by Western blot. D The expression of IFNβ mRNA in the lung caused by the indicated stimuli. Sham, IR, C-176, and vehicle are described above. ****P < 0.0001