From: Treatment of resistant chronic migraine with anti-CGRP monoclonal antibodies: a systematic review
1: Chronic migraine—no overuse of medication |
2: Use of prophylactic medication in adequate doses for at least 3Â months with each drug |
3: Lack of effect (or contraindications for use) of 2 to 4 drugs from each of the following groups after appropriate treatment# |
  A: β-blockers: propranolol, metoprolol, atenolol, bisoprolol |
  B: Anticonvulsants: sodium valproate, topiramate |
  C: Tricyclic antidepressants: amitriptyline |
  D: Others: flunarizine, candesartan |
  E: Botulinum toxin A |
4: Appropriate psychiatric treatment or other comorbidities carried out by a multidisciplinary group, if available |