Fig. 2

Establishment and verification of prognostic signature. A Venn diagram of the IBDGs that differentially expressed in CRC tumor and normal colorectal tissues, and significantly related to pathological stages and prognosis. B LASSO–Cox regression coefficient of prognostic signature. C, F Survival status, riskscores and prognostic signature expression levels of each patient in training and test cohort. D, G Kaplan–Meier survival curve between high and low riskscore patients in training and test cohort. E, H Time-dependent (1–5 years) ROC curve comparison of training and test cohort. I Univariate and multivariate Cox regression analyses of 7-gene signature and other prognostic factors for OS