Table 1 The detailed information of 10 CDK6 inhibitors from CLUE COMMAND
Name | Mechanism of action (MOA) | Target | Phase |
|---|---|---|---|
Abemaciclib | CDK inhibitor | CDK4, CDK6 | Launched |
Alvocidib | CDK inhibitor | CDK1, CDK2, CDK4, CDK5, CDK,6 CDK7, CDK8, CDK9, EGFR, PYGM | Phase 2 |
AMG-925 | CDK inhibitor, FLT3 inhibitor | CDK4, CDK6, FLT3 | Phase 1 |
Apigenin | Casein kinase inhibitor, cell proliferation inhibitor | AKR1B1, AR, CDK6, CFTR, CYP19A1, CYP1B1, HSD17B1 | Preclinical |
AT-7519 | CDK inhibitor | CDK1, CDK2, CDK4, CDK5, CDK6, CDK9 | Phase 2 |
Chrysin | Breast cancer resistance protein inhibitor | AKR1B1, CDK6, CYP19A1, CYP1B1 | Phase 1 |
Fisetin | Aurora kinase inhibitor | CDK6, FASN | Preclinical |
Palbociclib | CDK inhibitor | CDK4, CDK6 | Launched |
RGB-286638 | CDK inhibitor | CDK1, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK9, FLT3, GSK3B, JAK2, MAP3K7, MAPK9 | Phase 1 |
Ribociclib | CDK inhibitor | CDK4, CDK6 | Launched |