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Table 3 Treatment-related adverse events experienced by ≥ 20% patients

From: A phase Ib dose-escalation study of troriluzole (BHV-4157), an oral glutamatergic signaling modulator, in combination with nivolumab in patients with advanced solid tumors

Adverse event

All grades n (%)

Gr 2, n (%)

Gr 3, n (%)

Gr 4, n (%)

Elevated ALT

6 (42.9)

1 (7.1)

0 (0.0)

0 (0.0)

Elevated AST

5 (35.7)

1 (7.1)

1 (7.1)

0 (0.0)

Lipase increased

5 (35.7)

2 (14.3)

1 (7.1)

1 (7.1)

Fatigue

4 (28.6)

2 (14.2)

1 (7.1)

0 (0.0)

Diarrhea

3 (21.4)

1 (7.1)

0 (0.0)

0 (0.0)

Lymphocyte count decreased

3 (21.4)

2 (14.3)

0 (0.0)

0 (0.0)

Nausea

3 (21.4)

3 (21.4)

0 (0.0)

0 (0.0)

Platelet count decreased

3 (21.4)

0 (0.0)

0 (0.0)

0 (0.0)