Table 4 Potential of metabolic markers for the prediction or diagnosis of ICP
From: Application of metabolomics in intrahepatic cholestasis of pregnancy: a systematic review
References | Biospecimen | Potential Biomarker(s) or Biomarker Panel | AUC | Sensitivity | Specificity |
|---|---|---|---|---|---|
Ruirui Dong (2021) [13] | Serum | l-Palmitoylcarnitine | 0.896(the third trimester) | – | – |
0.657(the first trimester) | – | – | |||
0.727(the second trimester) | – | – | |||
Glycocholic acid | 0.985(the third trimester) | – | – | ||
0.686(the first trimester) | – | – | |||
0.670(the second trimester) | – | – | |||
l-Palmitoylcarnitine + Glycocholic acid + ACOX1a | 0.993(the third trimester) | – | – | ||
0.891(the first trimester) | – | – | |||
0.932(the second trimester) | – | – | |||
Yuchao Li (2018) [15] | Urine | Di-GBA-S-3 | 0.975 | 0.966 | 0.909 |
Glycocholic acid-3S | 0.997 | 1.000 | 0.955 | ||
Di-TBA-S-3 | 0.929 | 0.862 | 1.000 | ||
Di-TBA-S-2 | 0.983 | 0.966 | 1.000 | ||
Taurocholic acid-3S | 0.995 | 1.000 | 0.955 | ||
Cholic acid-3S | 0.873 | 0.793 | 0.955 | ||
Taurolithocholic acid-3S | 0.828 | 0.690 | 0.909 | ||
Li Ma (2017) [16] | Urine | 32 differential metabolites | 0.642–0.918 | – | – |
MG (22:5) + LysoPE (22:5) + L-Homocysteine sulfonic acid + Glycocholic acid + Chenodeoxycholic acid-3S | 0.988 | 0.900 | 0.933 | ||
Yue Cui (2018) [9] | Serum | Gtri-8 | 0.931 | 0.929 | 0.873 |
Taurochenodeoxycholic acid | 0.946 | 0.952 | 0.855 | ||
Ttri-5 | 0.940 | 0.833 | 0.909 | ||
Glycocholic acid | 0.957 | 0.929 | 0.891 | ||
Glycochenodeoxycholic acid | 0.917 | 0.881 | 0.891 | ||
Gtri-3 | 0.938 | 0.905 | 0.891 | ||
Tauro-ω-muricholic acid | 0.901 | 0.762 | 0.964 | ||
Taurocholic acid | 0.946 | 0.905 | 0.891 | ||
Gtri-7 | 0.924 | 0.810 | 0.946 | ||
α-Muricholic acid | 0.876 | 0.810 | 0.891 | ||
Gtri-6 | 0.950 | 0.905 | 0.873 | ||
Taurocholic acid + α-Muricholic acid + Gtri-8 | 0.996 | 0.976 | 0.964 | ||
Qihong Zheng (2021) [18] | Plasma | Norcholic acid | 0.900 | 0.781 | 0.929 |
Glycocholic acid | 0.994 | 0.969 | 1.000 | ||
Glycochenodeoxycholic acid | 0.977 | 0.938 | 0.929 | ||
Glycohyocholic acid | 0.998 | 1.000 | 0.964 | ||
Glycoursodeoxycholic acid | 0.894 | 0.813 | 0.857 | ||
Hyocholic acid | 0.819 | 0.594 | 1.000 | ||
Taurocholic acid | 1.000 | 1.000 | 1.000 | ||
Taurochenodeoxycholic acid | 1.000 | 1.000 | 1.000 | ||
Taurohyocholic acid | 0.992 | 0.938 | 1.000 | ||
Above 9 metabolites | 1.000 | 1.000 | 1.000 |