Fig. 6From: Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shockMechanism of alpha-adrenergic receptor signaling pathway. APE, acute pulmonary embolism; PASMC, pulmonary artery smooth muscle cell; NE, norepinephrine; PLC, phospholipase C; IP3, inositol 1,4,5-trisphosphate; PKA, protein kinase A; SERCA2, sarcoplasmic reticulum Ca2+-ATPase; PLN, phospholamban; CaM, calmodulin; MLCK, myosin light chain kinase; MLC, myosin light chain; PTL, phentolamine; SR, sarcoplasmic reticulumBack to article page