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Fig. 6 | European Journal of Medical Research

Fig. 6

From: Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shock

Fig. 6

Mechanism of alpha-adrenergic receptor signaling pathway. APE, acute pulmonary embolism; PASMC, pulmonary artery smooth muscle cell; NE, norepinephrine; PLC, phospholipase C; IP3, inositol 1,4,5-trisphosphate; PKA, protein kinase A; SERCA2, sarcoplasmic reticulum Ca2+-ATPase; PLN, phospholamban; CaM, calmodulin; MLCK, myosin light chain kinase; MLC, myosin light chain; PTL, phentolamine; SR, sarcoplasmic reticulum

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