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Table 1 Characteristics of the elderly individuals enrolled in this study

From: Transcriptome analysis of sputum cells reveals two distinct molecular phenotypes of “asthma and chronic obstructive pulmonary disease overlap” in the elderly

 

Asthma

ACO

COPD

P value

N = 17

N = 41

N = 12

Asthma vs. ACO

Asthma vs. COPD

ACO vs. COPD

Demographics

 Age, year

73.23 ± 3.54

73.51 ± 5.61

72.58 ± 6.18

NS

NS

NS

 Male, N

9 (52.94)

16 (39.02)

8 (66.67)

NS

NS

NS

 Height, cm

164.61 ± 6.76

157.44 ± 8.61

160.35 ± 8.81

0.0034

NS

NS

 BMI, m2/kg

23.45 ± 3.01

25.45 ± 3.78

24.06 ± 3.37

0.015

NS

NS

 Smoker, N

5 (29.41)

25 (60.97)

12 (100.00)

NS

NA

NA

Medications

 Low dose* ICS, N

1 (5.88)

0 (0)

0 (0)

NA

NA

NA

 Medium dose* ICS, N

13 (76.47)

28 (68.29)

3 (25.00)

NS

0.0074

0.0042

 High dose* ICS, N

3 (17.65)

13 (31.71)

2 (16.67)

NS

NS

NS

 Inhaled LAMA, N

0 (0)

35 (85.37)

12 (100.00)

NA

NA

NA

Lung function

 FVC, mL

2771.67 ± 908.34

2489.26 ± 778.25

3378.82 ± 674.35

NS

0.0012

NS

 FVCp, %

95 ± 22.67

94.65 ± 18.73

101.82 ± 21.43

NS

0.048

0.037

 FEV1, mL

1883.33 ± 557.07

1521.95 ± 484.60

1792.94 ± 384.60

NS

0.032

0.045

 FEV1p, %

91.5 ± 23.45

82.31 ± 25.74

75.52 ± 19.32

0.0062

2.7 × 10−4

0.014

 FEV1/FVC ratio, %

69.25 ± 10.11

62.73 ± 13.97

54.88 ± 12.18

0.0017

1.4 × 10−4

0.0098

Inflammatory markers

 Sputum neutrophil, %

33.19 ± 10.90

35.53 ± 13.70

43.76 ± 13.79

NS

0.0036

0.042

 Sputum eosinophil, %

6.02 ± 6.70

3.86 ± 6.37

0.97 ± 1.11

0.0027

5.7 × 10−5

0.016

 Blood eosinophil, %

4.53 ± 2.82

2.60 ± 2.07

3.01 ± 2.31

0.039

NS

NS

  1. Data are presented as the mean ± standard deviation (SD) except sex, smoking status, and medication (number [%])
  2. ACO asthma-COPD overlap, COPD chronic obstructive pulmonary disease, N number, BMI body mass index, ICS inhaled corticosteroid, LAMA long acting muscarinic antagonist, FVC forced vital capacity, FVCp FVC predicted value, FEV1 forced expiratory volume in one second, FEV1p FEV1 predicted value, NA not applicable, NS not significant
  3. *Based on the Global Initiative for Asthma guideline[10]