Table 2 Characteristics of ACO clusters 1 and 2 in the elderly
Cluster 1 | Cluster 2 | P value | |
|---|---|---|---|
N = 23 | N = 18 | ||
Demographics | |||
Age, year | 73.56 ± 5.42 | 73.44 ± 6.01 | NS |
Male, N | 11 (47.82) | 5 (27.78) | NS |
Height, cm | 157.30 ± 9.04 | 157.63 + 0 ± 8.28 | NS |
BMI, m2/kg | 26.27 ± 4.21 | 25.73 ± 3.25 | NS |
Smoker, N | 19 (82.61) | 6 (33.33) | 0.0038 |
Medications | |||
Medium dose* ICS, N | 15 (65.22) | 13 (72.22) | NS |
High dose* ICS, N | 8 (34.78) | 5 (27.78) | NS |
Inhaled LAMA | 20 (86.96) | 15 (83.33) | NS |
Lung function | |||
FVC, mL | 2567.82 ± 880.87 | 2388.89 ± 633.99 | NS |
FVCp, % | 97.52 ± 21.43 | 91.00 ± 14.61 | NS |
FEV1, mL | 1471.30 ± 384.60 | 1586.66 ± 460.74 | NS |
FEV1p, % | 79.13 ± 19.32 | 86.38 ± 24.93 | NS |
FEV1/FVC ratio, % | 59.21 ± 14.75 | 67.22 ± 11.82 | NS (0.068) |
Inflammatory markers | |||
Sputum neutrophil, % | 39.40 ± 14.03 | 30.59 ± 11.87 | NS (0.091) |
Sputum eosinophil, % | 5.34 ± 7.87 | 1.96 ± 2.89 | 0.039 |
Blood eosinophil, % | 2.93 ± 2.41 | 2.18 ± 1.52 | NS |